Population and experimental data
| Variable | Patient 1 | Patient 2 | Patient 3 | Controls (n=5) |
|---|---|---|---|---|
| Handedness | Right | Right | Left | Right |
| Lesion | Right ICA occlusion | Left ICA occlusion | Left MCA 70% stenosis | None |
| Perfusion results | ||||
| Arterial spin labeling (%) | −27 | −13 | −19 | R>L 3.3 +/− 2.5 |
| TCD acetazolamide challenge (L/R) | 100/24% | 3.7/4.5 ARI | 11/60% | NA |
| Event-related experiment | ||||
| % BOLD change (L/R) | 1.2/0.79* | 0.89/0.73 | 1.22/1.62* | 1.12/1.26 |
| Time to peak (L/R in sec) | 8.1/11* | 13/8.5* | 7.9/7.3 | 7.5/7.5 |
| Extent (L>R or R>L) | L≫R | R≫L | R>L | Same |
| Block experiment | ||||
| % BOLD change (L/R) | 2.3/1.53* | 0.93/1.1 | 1.35/3.3* | 2.35/2.17 |
| Extent (L>R or R>L) | Same | Same | R>L | Same |
Note.—ICA indicates internal carotid artery; MCA, middle cerebral artery; TCD, transcranial Doppler US; ARI, autoregulatory index; NA, not available; L, left; R, right.
TCD and arterial spin labeling perfusion results for the patients are relative to baseline and normal hemisphere, respectively; for control subjects, arterial spin labeling results are referenced to the right hemisphere. The BOLD signal change and time to peak were measured for the average hemodynamic response. The extent of the functional maps was determined qualitatively.
* Statistical significance of P < .01.