MR findings in acute MTX neurotoxicity
| Patient/Age | Symptoms | Site of Restricted Diffusion | Interval to Next MR Study | T2 Abnormalities on Next MR Study | Clinical Follow-Up (mo) |
|---|---|---|---|---|---|
| 1/15/F | Aphasia, bilateral arm weakness R < L | Bilateral posterior centrum semiovale | 13 mo | Minimal involvement of R cenetrum semiovale | 25 |
| 2/14/M | Aphasia, L upper-extremity weakness | Bilateral posterior centrum semiovale | 6 wk | Asymmetric involvement of centrum semiovale R > L | 9 |
| 3/15/F | |||||
| Initial | Aphasia, R-sided weakness | Bilateral posterior centrum semiovale | 8 wk | Bilateral centrum semiovale | 42 |
| Recurrence | Recurrence of aphasia, L hemiparesis, and focal seizure 8 wk later | R parietal cortex and white matter | 28 mo | Progressive involvement of centrum semiovale, normal cortex | |
| 4/14/M | Aphasia, fluctuating bilateral hemiparesis, L facial droop | Bilateral asymmetric anterior centrum semiovale | 39 mo | Minimal scattered involvement of bilateral centrum semiovale | 49 |
| 5/12/F | Aphasia, R-sided weakness, mild R facial droop | L precentral subcortical white matter | 13 mo | Minimal scattered involvement of bilateral centrum semiovale | 23 |