Overview of CTA protocols used in previous CTA-SI studies of acute stroke

Study	Sharma et al, AJNR 2011³	Pulli et al, Radiology 2011⁴	Pulli et al, Radiology2011⁴	Schramm et al, Stroke 2002⁵	Schramm et al, Stroke 2004⁶	Wittkamp et al, Acad Radiol 2010⁷
CT scanner	64-section	64-section	4- or 16-section	Single-section	4-section	64-section
Acquisition direction	Caudocranial	Craniocaudal	Caudocranial	Caudocranial	Caudocranial	N/A
Table speed	3.7 mm/s	9.38–39.38 mm/s	3.75–5.68 mm/s	N/A^{^a}	N/A^{^a}	61.35 mm/s
Contrast injection	≤90 mL at 5 mL/s	65–100 mL at 3–4 mL/s	95–140 at 3–3.5 mL/s	130 mL at 5 mL/s	40 mL at 5 mL/s, 25 mL at 2.5 mL/s	80 mL at 4 mL/s
Saline flush	40 mL at 5 mL/s	40 mL at 4 mL/s	None	None	None	50 mL at 4 mL/s
Injection duration	≤18 s	16–32 s	40–60 s	26 s	18 s	20 s
Delay time	5–10 s	SmartPrep,^{^b} aortic arch (average, 22 s)	25 s	17 s	17 s	Peak enhancement at superior sagittal sinus
Timing of CT perfusion relative to CTA	After	After (if performed)	After (if performed)	N/A	Before	Before
CTA-SI correlate	CTP-CBF	>MR-DWI	MR-DWI	MR-DWI	MR-DWI	CTP-CBV
Agreement with infarct core	Poor, overestimation	Poor, overestimation	Good	Good	Good	Good

Note:—N/A indicates not applicable.
↵a Although the investigators did not state the table speed in their work, it can be presumed to be relatively slow because scanners of this generation were not capable of acquiring at higher speeds.
↵b GE Healthcare, Milwaukee, Wisconsin.