Overview of main POC devices used to measure ACT
| Manufacturer | Device | ACT Test | Reagent | Detection Method | Remarks |
|---|---|---|---|---|---|
| International Technidyne | Hemochron Jr. Signature, Signature+, and Signature Elite | ACT and ACT-LR | Kaolin | Optical | Result is automatically converted to a reference Celite-ACT value |
| Hemochron Response | 3 different ACT tests: FTCA510, KACT, P214 | Celite in glass tube (high heparin levels), kaolin in glass tube (if aprotinin is present), glass beads in plastic tube (low heparin levels) | Mechanical | Other capabilities: RxDx heparin/protamine dosing system | |
| Hemochron Jr. Hemonox | Hemonox-CT | Proprietary lipidated recombinant–rabbit-brain tissue factor | Mechanical | Designed specifically to monitor LMWH | |
| Medtronic | HMS PLUS | ACT-HR | Celite | Mechanical | Other capabilities: heparin dose response and heparin protamine titration |
| ACT PLUS | ACT-LR | Celite | Mechanical | ||
| Sienco | Sonoclot | Aprotinin-insensitive ACT (SaiACT) | Celite + clay | Mechanical | |
| Abbott Laboratories | i-STAT | Celite-ACT, kaolin-ACT | Celite kaolin | Electrochemical | |
| Instrumentation Laboratory | GEM PCL | ACT, ACT-LR | Kaolin (for ACT), Celite + silica (for ACT-LR) | Optical | |
| Helena Laboratories | Cascade | Celite-ACT | Celite | Photomechanical | Can also perform Enox and LMWH tests |
| Actalyke XL, Actalyke Mini II | Celite-ACT, kaolin-ACT, glass-ACT, MAX-ACT | Celite, kaolin, glass, or a cocktail of Celite, kaolin and glass | 2-Point, electromechanical | Linear correlation with heparin level ≤10 U/mL for XL model and 6 U/mL for Mini II model tubes can be used in Hemochron system |
Note:—LR = low range; HR = high range.