Table 2:

Structural brain volume measures in patients with MS and healthy control patients

HC (n = 110)MS (n = 285)P Value
Global and tissue-specific brain structures
    NGMV, mean (SD) median762.4 (53.0) 759.8726.4 (66.0) 729<.001*
    NWMV, mean (SD) median757.1 (41.2) 757.6749.2 (73.1) 740.1.054
    NBPV, mean (SD) median1519.5 (82.7) 1515.61475.7 (93.5) 1474.4<.001*
    NLVV, mean (SD) median33.0 (12.6) 28.849.4 (22.4) 43.9<.001*
    NCV, mean (SD) median622.0 (45.6) 621.2587.8 (55.1) 590.8<.001*
Subcortical deep gray matter structures
    Total SDGM, mean (SD) median44.9 (5.4) 45.342.0 (5.4) 42.2<.001*
    Caudate, mean (SD) median6.7 (1.1) 6.76.2 (1.0) 6.2<.001*
    Putamen, mean (SD) median9.4 (1.4) 9.58.9 (1.3) 8.9.001*
    Globus pallidus, mean (SD) median3.5 (0.5) 3.53.2 (0.5) 3.2<.001*
    Thalamus, mean (SD) median14.9 (1.76) 14.913.8 (2.0) 13.9<.001*
    Hippocampus, mean (SD) median7.1 (0.9) 7.16.8 (0.9) 6.8.001*
    Amygdala, mean (SD) median2.4 (0.4) 2.42.4 (0.4) 2.4.355
    Nucleus accumbens, mean (SD) median0.8 (0.2) 0.80.7 (0.2) 0.7.042*

  • Note:——NBPV indicates normalized brain parenchymal volume; NCV, normalized cortical volume; NGMV, normalized gray matter volume; NLVV, normalized lateral ventricular volume; NWMV, normalized white matter volume.

  • Statistical analysis between groups was performed with use of the Mann-Whitney test for nonparametric data and the Student t test for parametric data. All P values were corrected for multiple comparisons using Benjamini-Hochberg correction.

  • The volumes are expressed in milliliters.

  • ↵* indicates significant P values (P < .05) after correction.