Basic descriptive statistics and neuropsychological scoresa
| HC | MCI | AD | ||||
|---|---|---|---|---|---|---|
| Mean | SD | Mean | SD | Mean | SD | |
| Age (yr) | 69.6b | 5.5 | 74.1 | 6.4 | 77.8c | 5.0 |
| Sex (M/F) | 3:8 | 9:2 | 5:3 | |||
| Years of education | 13 | 3.2 | 13.5 | 4.1 | 11.5 | 3.2 |
| MMSE score | 29.6b | 0.5 | 28.6 | 1.3 | 24.9c | 2.8 |
| APOE ϵ4 | 1/10 | 5/8 | 7/8 | |||
| TIV (cm3) | 1700 | 160 | 1800 | 120 | 1800 | 210 |
| Total ACE-R | 94.6b,d | 4.3 | 88.7b,c | 6.1 | 73.3c,d | 7.9 |
| ACE-R Memory | 23.7b,d | 2.2 | 19.5b,c | 3.6 | 11.1c,d | 2.9 |
| Category Fluency | 100b,d | 12.6 | 77.8b,c | 17.5 | 55.1c,d | 15.4 |
| ACE-R Attention | 18b | 0.0 | 17.8 | 0.4 | 16c | 1.9 |
Note:—HC indicates healthy controls; APOE ϵ4 indicates the number of participants carrying at least 1 ϵ4 allele (APOE data were unavailable from 1 healthy control and 3 patients with MCI); MMSE, Mini-Mental State Examination; TIV, total intracranial volume.
↵a Superscript symbols indicate significant pair-wise comparisons revealed by post hoc testing (Tamhane T2, P = .05). There was a significant group difference for age, F(2, 27) = 4.5, P < .05; MMSE score, F(2, 27) = 20.2, P < .001; total ACE-R, F(2, 27) = 29.9, P < .001; ACE-R Memory, F(2, 27) = 42.2, P < .001; Category Fluency, F(2, 27) = 20.1, P < .001; ACE-R Attention, F(2, 27) = 11.4, P < .001.
↵b Significantly different from AD.
↵c Significantly different from HC.
↵d Significantly different from MCI.