Table 1:

Clinical and radiologic characteristics of patients with SPMS

	Without Cognitive Impairment (n = 20)	With Cognitive Impairment (n = 25)	P Value
Age (y)	54.5 (49.3−62.3)	55.0 (47.5−61.5)	.954^{^a}
Sex (F/M)	11/9	16/9	.540^{^b}
Education level (y)	15.5 (13.0−17.8)	14.0 (13.0−17.0)	.619^{^a}
Disease duration (y)	18.5 (10.5−20.8)	19.0 (12.0−28.5)	.192^{^a}
EDSS (score)	6.0 (6.0−6.5)	6.5 (6.0−6.5)	.249^{^a}
BDI (score)	6.5 (5.0−11.8)	9.0 (7.5−13.5)	.067^{^a}
Normalized GM volume (%)	41.8 (41.5−42.9)	40.5 (38.7−41.6)	.001^{^a}
Normalized WM volume (%)	34.2 (33.9−35.1)	33.8 (33.3−34.3)	.024^{^a}
Normalized T2-weighted WML volume (%)	0.40 (0.08−0.94)	1.05 (0.63−1.78)	.002^{^a}
Normalized T1-weighted WML volume (%)	0.12 (0.03−0.32)	0.44 (0.13−0.67)	.006^{^a}
WM skeleton FA (mean)	0.37 (0.34−0.38)	0.33 (0.28−0.34)	<.001^{^a}

Note:— EBSS indicates Expanded Disability Status Scale; BDI, Beck Depression Inventory.
↵a Wilcoxon rank-sum test (median [interquartile range]).
↵b Pearson χ² test.