Table 2:

Clinical and radiologic data for matched pairs

	rtPA-Treated (N = 12)	Control (N = 12)	P Value
Clinical characteristics
Age (yr) (mean ± SEM)	52.8 ± 2.0	57.5 ± 1.9	.21
Sex, male/female	11:1	7:5	.06
Admission GCS (median) (IQR)	8.5 (6)	5.5 (4.5)	.06
Radiographic characteristics
ICH location
Basal ganglia	2	3	.57
Caudate	3	1
Thalamus	7	8
Admission Graeb score (median) (IQR)	8 (1.5)	8 (4)	.19
Total IVH volume (cm³) (mean ± SEM)¹²
t0	26.0 ± 2.51	26.34 ± 3.24	.87
t1	13.56 ± 2.70	25.20 ± 3.73	.005^{^a}
t2	6.26 ± 1.36	18.63 ± 2.83	.002^{^a}
Total ventricular volume (cm³) (mean ± SEM)
t0	69.13 ± 5.85	84.11 ± 8.40	.18
t1	34.78 ± 4.96	56.57 ± 5.70	.01^{^a}
t2	24.80 ± 2.67	57.57 ± 10.32	.01^{^a}
Hematoma (ICH) volume (cm³) (mean ± SEM)
t0	12.93 ± 3.59	14.29 ± 3.23	.39
t1	14.21 ± 3.93	14.92 ± 2.97	.74
t2	11.17 ± 3.64	13.76 ± 3.19	.29
IVH HU counts (mean ± SEM)
t0	52.71 ± 1.18	52.05 ± 0.96	.70
t1	49.01 ± 0.98	50.42 ± 1.55	.35
t2	45.05 ± 1.24	49.48 ± 1.33	.02
ICH HU counts (mean ± SEM)
t0	56.24 ± 1.84	54.12 ± 1.17	.25
t1	55.79 ± 1.08	52.80 ± 1.08	.04^{^a}
t2	52.06 ± 1.28	52.56 ± 1.10	.77
Radiologic outcomes
Change in IVH volume (cm³) (median) (IQR)
Days 2–4 (t1–t0)	−10.88 (12.84)	−1.24 (2.78)	.002^{^a}
Days 5–9 (t2–t0)	−18.65 (14.88)	−6.85 (6.36)	.002^{^a}
Change in ICH volume (cm³) (median) (IQR)
Days 2–4 (t1–t0)	0.24 (1.91)	−.06 (2.99)	.88
Days 5–9 (t2–t0)	−1.98 (3.25)	−1.15 (2.33)	.27
Change in IVH HU counts (mean ± SEM)
Days 2–4 (t1–t0)	−3.70 ± 1.44	−1.63 ± 1.50	.07
Days 5–9 (t2–t0)	−7.66 ± 1.87	−2.58 ± 1.23	.02^{^a}
Change in ICH HU counts (mean ± SEM)
Days 2–4 (t1–t0)	−0.59 ± 1.55	−1.31 ± 1.51	.63
Days 5–9 (t2–t0)	−4.18 ± 2.23	−1.55 ± 1.39	.25

Note:—GCS indicates Glasgow Coma Scale.
↵a Significant.