Comparison of the presence and absence of early neurologic improvement after IV rtPA in patients with proximal middle cerebral artery occlusiona
| Early Neurologic Improvement | P Value | ||
|---|---|---|---|
| Yes (n = 22) | No (n = 26) | ||
| Age (yr) ( median) (IQR) | 78.5 (74–81) | 78.5 (68–84) | .92 |
| Male sex (No.) (%) | 10 (45) | 16 (62) | .38 |
| mRS 0–1 before stroke (No.) (%) | 22 (100) | 25 (96) | 1 |
| NIHSS score at arrival (median) (mean) | 17.9 ± 8.1 | 16.0 ± 5.7 | .29 |
| Systolic blood pressure (mean) | 161.3 ± 29.6 | 155.0 ± 30.8 | .91 |
| Diastolic blood pressure (mean) | 88.5 ± 26.1 | 78.3 ± 21.9 | .19 |
| Temperature (°C) (mean) | 36.3 ± 0.4 | 36.2 ± 0.7 | .75 |
| Cardiovascular risk factors (No.) (%) | |||
| Hypertension | 14 (64) | 14 (54) | .57 |
| Diabetes mellitus | 7 (27) | 4 (15) | .48 |
| Hyperlipidemia | 5 (23) | 6 (23) | 1 |
| Atrial fibrillation | 19 (86) | 15 (58) | .054 |
| Congestive heart failure | 4 (18) | 5 (19) | 1 |
| Previous stroke | 5 (23) | 7 (27) | 1 |
| Smoking | 6 (27) | 12 (48) | .23 |
| Past medication at stroke onset (No.) (%) | |||
| Antiplatelet therapy | 8 (36) | 7 (27) | .54 |
| Anticoagulant therapy | 4 (18) | 5 (19) | 1 |
| Antihypertensive therapy | 14 (64) | 9 (35) | .08 |
| Statin therapy | 2 (9) | 4 (15) | .67 |
| Stroke etiology (No.) (%) | |||
| Cardioembolism | 17 (77) | 13 (50) | .074 |
| Atherosclerosis | 4 (18) | 8 (31) | .5 |
| Other or undetermined | 1 (5) | 5 (19) | .2 |
| Imaging analysis | |||
| Initial DWI volume (mL) (median) (IQR) | 19.8 (11.5–42.3) | 22.7(13.9–41.2) | .26 |
| DWI ASPECTS at arrival (median) (IQR) | 8 (6.75–9) | 8 (6.75–8) | .33 |
| MCA M1 occlusion (No.) (%) | 18 (82) | 17 (65) | .33 |
| Development of collaterals at arrival (No.) (%)c | 15 (68) | 9 (35) | .042b |
| Stroke outcome | |||
| Follow-up CT ASPECTS (median) (IQR) | 8 (6–9.25) | 6 (4.75–8) | .004d |
| mRS 0–1 at 3 mo (No.) (%) | 16 (73) | 8 (31) | .008d |
↵a For continuous variables, the median and P values (Mann-Whitney U test) are shown. The resulting proportions and the P values (Fisher exact test with Yates correction, when appropriate) are shown.
↵b P < .05.
↵c The development of collaterals was defined as positive in the presence of PCA laterality and an HV score of ≥5 on initial MRI.
↵d P <.01 was considered significant.