Table 3:

Group differences in diffusivity indices from VOIs

Anatomic RegionHemisphereAD (×10−3mm2/s) (Mean)RD (×10−3mm2/s) (Mean)MD (×10−3mm2/s) (Mean)
HIV−HIV+P ValueHIV−HIV+P ValueHIV−HIV+P Value
Genu of corpus callosumBilateral1.62 ± 0.081.58 ± 0.08.160.36 ± 0.030.40 ± 0.06.0040.78 ± 0.030.79 ± 0.05.22
Body of corpus callosumBilateral1.78 ± 0.061.78 ± 0.06.990.41 ± 0.050.49 ± 0.07.0003a0.87 ± 0.040.92 ± 0.05.002a
SpleniumBilateral1.66 ± 0.061.67 ± 0.05.410.33 ± 0.030.37 ± 0.04.0003a0.77 ± 0.020.80 ± 0.03.001a
Superior corona radiataLeft1.21 ± 0.041.20 ± 0.03.330.53 ± 0.020.56 ± 0.04.0003a0.76 ± 0.020.78 ± 0.03.01
Superior corona radiataRight1.26 ± 0.051.26 ± 0.04.780.49 ± 0.020.53 ± 0.03.00009a0.74 ± 0.020.77 ± 0.02.001a
Posterior corona radiataLeft1.23 ± 0.061.23 ± 0.03.810.59 ± 0.030.62 ± 0.03.002a0.80 ± 0.030.82 ± 0.02.02
Posterior corona radiataRight1.26 ± 0.041.25 ± 0.03.320.57 ± 0.030.61 ± 0.04.002a0.80 ± 0.030.82 ± 0.04.05
Frontal WMLeft1.35 ± 0.071.32 ± 0.05.220.44 ± 0.030.48 ± 0.04.001a0.74 ± 0.030.76 ± 0.03.09
Frontal WMRight1.37 ± 0.061.32 ± 0.07.020.40 ± 0.030.48 ± 0.03.0003a0.72 ± 0.030.73 ± 0.03.21
Pre-/postcentral gyrus WMLeft1.32 ± 0.061.29 ± 0.06.140.47 ± 0.030.50 ± 0.03.0007a0.75 ± 0.020.76 ± 0.02.06
Pre-/postcentral gyrus WMRight1.30 ± 0.041.27 ± 0.04.010.44 ± 0.020.48 ± 0.03.00009a0.73 ± 0.020.74 ± 0.02.08
Parietal WMLeft1.31 ± 0.051.31 ± 0.05.940.57 ± 0.040.61 ± 0.03.001a0.82 ± 0.030.84 ± 0.03.02
Parietal WMRight1.29 ± 0.061.27 ± 0.04.280.58 ± 0.030.62 ± 0.05.002a0.81 ± 0.030.84 ± 0.04.07
SLFLeft1.11 ± 0.041.09 ± 0.03.130.54 ± 0.030.57 ± 0.04.0040.73 ± 0.020.75 ± 0.03.05
  • Note:—HIV- indicates HIV-negative controls; HIV+, HIV-positive subjects.

  • a P < .05/14 ≈ .0035 (Bonferroni-corrected for multiple comparisons).