Table 3:

Diagnostic performance of the DCE pharmacokinetic parameters in detecting true progression

Pharmacokinetic Parameter	T1 Method	Median AUC	Optimal Threshold Value	Sensitivity [%]	Specificity [%]	P Value^{^a}
K^trans, min⁻¹	Fixed	0.694	0.093	53.3	86.4	.03^{^b}
	Measured	0.664	0.059			.08
K_ep, min⁻¹	Fixed	0.752	0.184	80.0	63.6	.002^{^b}
	Measured	0.603	0.159			.28
V_p, %	Fixed	0.552	3.423			.62
	Measured	0.609	0.597			.25
V_e	Fixed	0.518	0.349			.86
	Measured	0.606	0.546			.30

Note:—V_e indicates extravascular extracellular space per unit volume; V_p, blood plasma volume per unit volume.
↵a P values are from the receiver operating characteristics analysis.
↵b Significant P value for each test.