Table 2:

Comparison of the DCE pharmacokinetic parameters of patients with true progression versus pseudoprogression

Pharmacokinetic Parameter	T1 Method	True Progression (n = 15)		Pseudoprogression (n = 22)		P Value^{^a}	Intraclass Correlation Coefficient [95% CI]
Pharmacokinetic Parameter	T1 Method	Mean ± SD	Median [range]	Mean ± SD	Median [range]	P Value^{^a}	Intraobserver	Interobserver
K^trans, min⁻¹	Fixed	0.138 ± 0.148	0.096 [0.042–0.579]	0.068 ± 0.043	0.064 [0.0005–0.154]	.05^{^b}	0.893 [0.792–0.945]	0.897 [0.799–0.947]
	Measured	0.126 ± 0.139	0.069 [0.025–0.499]	0.056 ± 0.045	0.058 [0.0001–0.194]	.10	0.923 [0.850–0.960]	0.943 [0.888–0.970]
K_ep, min⁻¹	Fixed	0.321 ± 0.244	0.244 [0.135–1.082]	0.179 ± 0.103	0.179 [0.024–0.483]	.01^{^b}	0.910 [0.825–0.954]	0.929 [0.862–0.963]
	Measured	0.224 ± 0.108	0.202 [0.035–0.396]	0.192 ± 0.148	0.157 [0.009–0.494]	.47	0.861 [0.729–0.928]	0.882 [0.771–0.939]
V_p, %	Fixed	3.309 ± 4.429	1.468 [0.709–18.298]	1.998 ± 1.462	1.705 [0.140–6.723]	.60	0.872 [0.752–0.934]	0.888 [0.784–0.943]
	Measured	2.358 ± 2.701	1.339 [0.478–10.407]	1.521 ± 1.456	1.134 [0.081–6.056]	.27	0.800 [0.605–0.895]	0.688 [0.394–0.839]
V_e	Fixed	0.536 ± 0.330	0.446 [0.168–1.050]	0.506 ± 0.284	0.482 [0.114–1.156]	.77	0.761 [0.537–0.877]	0.718 [0.516–0.844]
	Measured	0.550 ± 0.511	0.377 [0.121–1.192]	0.316 ± 0.265	0.270 [0.041–1.297]	.08	0.937 [0.877–0.968]	0.936 [0.875–0.967]

↵a P values are from Student t test when the variables satisfied normality (K_ep from measured T1 and V_e from fixed T1) or from Mann-Whitney U tests otherwise, according to Kolmogorov-Smirnov test.
↵b Significant P value for each test.