Baseline characteristics (unadjusted) of the studied patient population as stratified by the presence-versus-absence of proximal LVOa
| Characteristics | All Patients (n = 274) | LVO (n = 46) | No LVO (n = 228) | P Value |
|---|---|---|---|---|
| Age (yr) | 69 (60–80) | 68 (58–77) | 70 (60–81) | .347 |
| Female sex | 126 (46%) | 24 (52%) | 102 (45%) | .418 |
| Admission NIHSS score | 5 (2–10) | 14 (4–17) | 4 (2–9) | <.001 |
| Prestroke mRS | 0 (0–1) | 0 (0–1) | 0 (0–1) | .774 |
| LVO stroke scale scores | ||||
| 3I/SS | 1 (0–2) | 2 (1–3) | 1 (0–2) | <.001 |
| VAN | 0 (1–2) | 3 (0–4) | 0 (0–2) | <.001 |
| CPSSS | 0 (0–1) | 1 (0–3) | 0 (0–1) | .001 |
| FAST-ED | 2 (0–4) | 4 (2–6) | 1 (0–3) | <.001 |
| RACE | 2 (0–4) | 5 (1–7) | 1 (0–3) | <.001 |
| Laboratory data | ||||
| Admission glucose level (mg/dL) | 119 (100–142) | 120 (105–143) | 119 (99–142) | .515 |
| Admission creatinine level (mg/dL) | 0.95 (0.78–1.20) | 0.90 (0.73–1.0) | 0.97 (0.79–1.20) | .090 |
| HbA1c level (%) (n = 161) | 5.9 (5.7–6.5) | 6.0 (5.6–6.3) | 5.9 (5.7–6.6) | .794 |
| LDLc level (mg/dL) (n = 171) | 93 (72–123) | 89 (65–111) | 94 (74–123) | .274 |
| Neuroimaging | ||||
| Fazekas scale score (0–2) | 129 (48%) | 30 (65%) | 99 (43%) | .009 |
| Pre-existing risk factors | ||||
| Hypertension | 210 (77%) | 34 (74%) | 176 (77%) | .703 |
| Hyperlipidemia | 152 (56%) | 26 (57%) | 132 (58%) | .076 |
| Diabetes | 75 (27%) | 11 (24%) | 64 (28%) | .594 |
| Prior stroke or TIA | 59 (22%) | 6 (13%) | 53 (23%) | .168 |
| Atrial fibrillation | 42 (15%) | 8 (17%) | 34 (15%) | .823 |
| Coronary artery disease | 58 (21%) | 4 (9%) | 54 (24%) | .028 |
| Congestive heart failure | 20 (7%) | 1 (2%) | 19 (8%) | .215 |
| Peripheral arterial disease | 18 (7%) | 1 (2%) | 17 (8%) | .221 |
| Preadmission medications | ||||
| Statin | 124 (45%) | 19 (41%) | 105 (46%) | .689 |
| Antihypertensive | 185 (67%) | 32 (70%) | 153 (67%) | .863 |
| Antiglycemic | 53 (19%) | 9 (20%) | 44 (19%) | 1.000 |
| Antiplatelets | 145 (53%) | 24 (52%) | 121 (53%) | 1.000 |
| Oral anticoagulant | 19 (7%) | 4 (9%) | 15 (7%) | .749 |
Note:—HbA1c indicates glycated hemoglobin A1c; LDLc, low-density lipoprotein cholesterol.
↵a Proximal LVO is defined as an occlusion of the internal carotid artery or middle cerebral artery M1 segment. Data are No. (%) or median (25th–75th percentile).