1H-MRS white matter parieto-occipital metabolite absolute concentrations, ratios, and water signal intensity, and T2 values in patients with MNGIE and healthy controls
| Patients with MNGIE (n = 7) (mean ± SD) | Healthy Controls (n = 9) (mean ± SD) | P Valuea | |
|---|---|---|---|
| Metabolite concentrations (mM) | |||
| NAA | 6.98 ± 0.79 | 9.81 ± 0.94 | <.001a,c |
| Cr | 4.15 ± 0.48 | 5.97 ± 0.55 | <.001a,c |
| Cho | 1.53 ± 0.23 | 1.89 ± 0.24 | .01a |
| mIns | 4.46 ± 1.14 | 5.44 ± 0.76 | .06a |
| Metabolite ratios | |||
| NAA/Cr | 1.85 ± 0.18 | 1.80 ± 0.11 | .57b |
| Cho/Cr | 0.39 ± 0.06 | 0.33 ± 0.04 | .04b |
| mIns/Cr | 0.99 ± 0.27 | 0.85 ± 0.08 | .16b |
| Water signal (a.u.) | |||
| SBW (0) | (14.0 ± 9.0)×1010 | (10.8 ± 2.0)×1010 | .370 |
| SCSF (0) | (4.0 ± 7.5)×1010 | (1.3 ± 0.6)×1010 | .23a |
| T2 water | |||
| T2BW (ms) | 112 ± 24 | 75 ± 8 | .001a,c |
| T2CSF (ms) | 520 ± 185 | 776 ± 344 | .098a |
Note:—a.u. indicates arbitrary units; SBW (0) and SCSF (0), water signals corresponding to brain and cerebrospinal water, respectively; T2BW and T2CSF, water relaxation times corresponding to brain and cerebrospinal water, respectively.
↵a Statistical significance was set at P < .0125 after Bonferroni correction for multiple comparisons.
↵b Statistical significance was set at P < .0167 after Bonferroni correction for multiple comparisons.
↵c Significant.