Mean ihMTR and MTR values calculated in the 7 ROIs of the ihMT atlas and in lesionsa
| Brain Structure | ihMTR (%) | MTR (%) | ||
|---|---|---|---|---|
| Controls | Patients | Controls | Patients | |
| IC | 7.8 ± 0.3 | 7.6 ± 0.4 | 45.2 ± 0.6 | 44.7 ± 0.8 |
| P = .16 | P = .02b | |||
| TEMPWM | 8.0 ± 0.3 | 7.3 ± 0.7 | 46.3 ± 0.6 | 44.2 ± 1.9 |
| P < .001b | P < .001b | |||
| FWM | 7.7 ± 0.3 | 7.4 ± 0.5 | 47.5 ± 0.7 | 46.2 ± 1.4 |
| P = .01b | P = .01b | |||
| OCCWM | 7.6 ± 0.4 | 7.0 ± 0.6 | 44.6 ± 0.7 | 43.4 ± 1.5 |
| P = .004b | P = .005b | |||
| CC | 6.5 ± 0.6 | 6.0 ± 0.7 | 43.7 ± 2.2 | 41.9 ± 2.7 |
| P = .09 | P = .07 | |||
| Thalami | 5.6 ± 0.2 | 5.1 ± 0.4 | 43.3 ± 0.8 | 41.0 ± 2.2 |
| P < .001b | P < .001b | |||
| Putamen | 4.6 ± 0.3 | 4.9 ± 0.4 | 42.0 ± 0.8 | 42.4 ± 0.7 |
| P =.03 | P = .09 | |||
| Lesions | NA | 6.3 ± 0.9c | NA | 39.9 ± 3.6c |
Note:—NA indicates not applicable.
↵a ihMTR and MTR data are expressed as mean value ± SD. Between-group comparison (P value): comparison of mean ihMTR and MTR between patients with RRMS and controls was assessed by the nonparametric Wilcoxon rank test (α = .05) corrected by the Holm-Bonferroni method for multiple comparisons (m = 7 brain structures).
↵b Statistically significant.
↵c Within-patient group: ihMTR and MTR values in lesions statistically different (Kruskal-Wallis test corrected for multiple comparisons using the Steel-Dwass procedure) from values in all normal-appearing WM structures (P < .05) except the corpus callosum (P > .5).