Table 4:

Summary of ROC analysis for 3 lesion pools

LL Lesion PoolNC Lesion PoolSV Lesion Pool
Infratentorial region
    Threshold; sensitivity, 95% CI>13%; 29%, 10%–56%>13%; 12%, 2%–36%>13%; 6%, 0%–29%
    Specificity, 95% CI100%, 82%–100%100%, 82%–100%100%, 82%–100%
    AUC0.650.560.53
Juxtacortical region
    Threshold; sensitivity, 95% CI>19%; 82%, 57%–96%>7%; 82%, 57%–96%,>29%; 65%, 38%–86%
    Specificity, 95% CI89%, 65%–99%89%, 65%–99%100%, 82%–100%
    AUC0.930.890.86
Periventricular region
    Threshold; sensitivity, 95% CI>13%; 88%, 64%–99%>13%; 82%, 57%–96%>13%; 53%, 28%–77%
    Specificity, 95% CI83%, 59%–96%94%, 73%–100%100%, 82%–100%
    AUC0.930.900.77
Subcortical region
    Threshold; sensitivity, 95% CI>51%; 94%, 71%–100%>61%; 94%, 71%–100%>61%; 82%, 57%–96%
    Specificity, 95% CI100%, 82%–100%100%, 82%–100%100%, 82%–100%
    AUC0.990.990.96
Averaged results (over brain volume)
    Threshold; sensitivity, 95% CI>30%; 94%, 71%–100%>67%; 94%, 71%–100%>66%; 77%, 50%–93%
    Specificity, 95% CI100%, 82%–100%100%, 82%–100%100%, 82%–100%
    AUC0.990.990.95

  • Note:—AUC indicates area under the receiver operating characteristic curve.