Exploratory analysis of patients stratified by hemorrhage occurrence at 24-hour follow-upa
Hemorrhage on 24-Hour Follow-Up (n = 46) | No Hemorrhage (n = 153) | P Value | |
---|---|---|---|
Age (yr) | 71 (63–77) | 69 (59–78) | .875 |
Female (No.) (%) | 27 (56.5%) | 62 (40.5%) | .055 |
Medical history (No.) (%) | |||
Hypertension | 31 (67.4%) | 86 (56.2%) | .177 |
Previous stroke/TIA | 4 (8.7%) | 29 (18.9%) | .101 |
Antiplatelet use | 13 (28.3%) | 53 (34.6%) | .420 |
Anticoagulant use | 6 (13.0%) | 26 (16.9%) | .523 |
Clinical information | |||
Serum glucose level (mmol/L) | 7.2 (6.1–8.3) | 6.2 (5.5–7.2) | <.001 |
Low density lipoprotein levelb | 2.1 (1.5–2.9) | 2.3 (1.9–2.9) | .348 |
International normalized ratio | 1.0 (0.9–1.1) | 1.0 (1.0–1.1) | .756 |
Partial thromboplastin time (sec)c | 27 (24–31) | 28 (25–30) | .985 |
Platelet count | 205 (159–248) | 200 (166–247) | .788 |
Clinical course | |||
Baseline NIHSS | 19 (15–21) | 17 (12–20) | .084 |
Systolic blood pressure (mm Hg)d | 148 (128–167) | 140 (125–160) | .306 |
Administration of IV tPA (No.) (%) | 35 (76.1%) | 125 (81.7%) | .400 |
General anesthesia (No.) (%) | 4 (9.3%) | 12 (8.4%) | .852 |
Recanalization (No.) (%) | 41 (89.1%) | 144 (94.1%) | .246 |
Onset to recanalization (min) | 203 (141–314) | 150 (111–216) | .001 |
Imaging | |||
Baseline ASPECTSc | 8 (7–9) | 9 (8–10) | <.001 |
CBSc | 4 (1–6) | 6 (4–8) | .014 |
Location of occlusion (No.) (%) | |||
Internal carotid artery | 21 (45.7%) | 40 (26.1%) | .012 |
Proximal M1 segment | 14 (30.4%) | 51 (33.3%) | .713 |
Distal M1 segment | 5 (10.9%) | 29 (19.0%) | .201 |
M2 horizontal segment | 3 (6.5%) | 24 (15.7%) | .111 |
M2 Sylvian segment | 3 (6.5%) | 9 (5.9%) | .873 |
Residual flow grade (No.) (%) | |||
Grade 0 | 41 (89.1%) | 123 (80.4%) | .355 |
Grade 1 | 3 (6.5%) | 14 (9.2%) | |
Grade 2 | 2 (4.4%) | 16 (10.5%) | |
Collateral grade (No.) (%) | |||
Good | 9/14 (64.3%) | 44/61 (72.1%) | .664 |
Intermediate | 4/14 (28.6%) | 11/61 (18.0%) | |
Poor | 1/14 (7.1%) | 6/61 (9.8%) |