MR imaging characteristics of multinodular and vacuolating posterior fossa lesions of unknown significance (MV-PLUS) at diagnosis and during follow-up
| No. of Patients | Percentage (%) | |
|---|---|---|
| Location | ||
| Center of the lesion | ||
| Cerebellum | ||
| Vermis | 7/11 | 64 |
| Left cerebellar hemisphere | 1/11 | 9 |
| Right cerebellar hemisphere | 2/11 | 18 |
| Left cerebellar peduncle | 1/11 | 9 |
| Right cerebellar peduncle | 0/11 | 0 |
| Brain stem | 0/11 | 0 |
| All areas involved | ||
| Cerebellum | ||
| Vermis | 7/11 | 64 |
| Left cerebellar hemisphere | 3/11 | 27 |
| Right cerebellar hemisphere | 8/11 | 73 |
| Left cerebellar peduncle | 1/11 | 9 |
| Right cerebellar peduncle | 0/11 | 0 |
| Brain stem | 0/11 | 0 |
| Overall size (median) (IQR) (mm) | 27 (24) | |
| Size of the nodules (median) (IQR) (mm) | 4 (5) | |
| DWI | ||
| Restriction | 0/11 | 0 |
| T2* or SWI | ||
| Presence of ITSS | 0/11 | 0 |
| Blooming | 0/11 | 0 |
| PWI | ||
| rCBV (median) (IQR) | 0.62 (0.06) | |
| rCBF (median) (IQR) | 0.61 (0.06) | |
| MRS | ||
| TE = 35 ms | ||
| Choline/creatine (median) (IQR) | 0.9 (0.2) | |
| Choline/N-acetyl aspartate (median) (IQR) | 0.9 (0.1) | |
| N-acetyl aspartate/creatine (median) (IQR) | 1 (0.2) | |
| TE = 135 ms | ||
| Choline/creatine (median) (IQR) | 1.2 (0) | |
| Choline/N-acetyl aspartate (median) (IQR) | 1 (0) | |
| N-acetyl aspartate/creatine (median) (IQR) | 1.2 (0) | |
| Type of margins | ||
| Sharp | 11/11 | 100 |
| Blurred | 0/11 | 0 |
| Mass effect | ||
| Yes | 4/11 | 36 |
| No | 7/11 | 64 |
| Associated imaging abnormalities | ||
| None | 7/11 | 64 |
| Small-vessel disease | 3/11 | 27 |
| Colloid cyst | 1/11 | 9 |
| Cholesteatoma | 1/11 | 9 |
Note:—ITSS indicates intratumoral susceptibility signal; rCBV, relative CBV; rCBF, relative CBF.