Demographic and structural variables in healthy and midline abnormality groups
| Healthy Group (Avg ± SD) | Midline Group (Avg ± SD) | Total (Avg ± SD) | P | |
|---|---|---|---|---|
| Age (yr) | 11.7 ± 5.3 | 4.1 ± 5.5 | 7.9 ± 6.6 | .001 |
| Sex | n = 55 f (52%) | n = 52 f (50%) | n = 107 f (51%) | .78 |
| MI present | n = 92 (88%) | n = 62 (60%) | n = 154 (74%) | .001 |
| Morphology | n = 89 (n); 3(T) | n = 45 (n); 10(T); 7(t) | n = 134 (n); 13(T); 7(t) | .001 |
| tr (mm) | 1.5 ± 0.2 | 2 ± 0.2 | 1.7 ± 1 | .002 |
| ap (mm) | 7.3 ± 2.3 | 6.8 ± 3.9 | 7 ± 3.1 | .144 |
| cc (mm) | 6.7 ± 5.6 | 6.1 ± 3.5 | 6.4 ± 4.9 | .202 |
| Area (mm2) | 42.9 ± 23.9 | 44.2 ± 48.9 | 43.2 ± 35.9 | .458 |
| Location | n = 84 (a/s); 6 (p/s); 2 (p/i) | n = 34 (a/s); 14 (p/s); 3 (p/i); 1 (a/i); 10 (all) | n = 118 (a/s); 20 (p/s); 5 (p/i); 1 (a/i); 10 (all) | .001 |
| CC present | n = 105 (100%) | n = 70 (68%) | n = 175 (84%) | .001 |
| Morphology | n = 105 (n) | n = 13 (n); 6 (h); 46 (h/d); 5 (d) | n = 118 (n); 6 (h); 46 (h/); (5d) | .001 |
| Length (mm) | 68.2 ± 7.6 | 39.9 ± 21.5 | 57 ± 20.2 | .001 |
| Genu (mm) | 10.5 ± 2 | 7.4 ± 10 | 9.3 ± 6.6 | .007 |
| Body (mm) | 5.7 ± 1.2 | 3.5 ± 2.2 | 4.9 ± 1.9 | .001 |
| Splen (mm) | 10.3 ± 2 | 4.7 ± 2.9 | 8.4 ± 3.6 | .001 |
| Area (mm2) | 546 ± 129 | 214 ± 199 | 415 ± 228 | .001 |
| AC present | n = 105 (100%) | n = 101 (98%) | n = 206 (99%) | .151 |
| Morphology | n = 105 (n) | n = 41 (n); 53 (h); 7 (T) | n = 146 (n); 53 (h); 7 (T) | .001 |
| tr (mm) | 1.8 ± 0.4 | 3.9 ± 1.5 | 2.8 ± 1.5 | .001 |
| ap (mm) | 2.6 ± 0.7 | 1.7 ± 1.1 | 2.2 ± 1 | .001 |
| cc (mm) | 3.5 ± 1 | 2.2 ± 1.3 | 2.9 ± 1.3 | .001 |
| Area (mm2) | 8.1 ± 3.8 | 4.4 ± 5.1 | 6.3 ± 4.9 | .001 |
| Septum pellucidum | n = 96 (n); 9 (c) | n = 13 (n); 7 (c); 47 (a); 36 (h) | n = 109 (n); 16 (c); 47 (a); 36 (h) | .001 |
| Fornix | n = 105 (n) | n = 36 (n); 25 (a); 42 (h) | n = 141 (n); 25 (a); 42 (h) | .001 |
| Hypothalamus | n = 105 (n) | n = 84 (n); 19 (IHA) | n = 189 (n); 19 (IHA) | .001 |
| Hippocampus | n = 87 (n); 18 (u) | n = 11 (n); 88 (u); 2 (d); 2 (mts) | n = 98 (n); 106 (u); 2 (d); 2 (mts) | .001 |
| Brain stem | n = 105 (n) | n = 67 (n); 18 (h); 18 (d) | n = 172 (n); 18 (h); 18 (d) | .001 |
| Vermis | n = 105 (n) | n = 77 (n); 15 (h); 11 (d) | n = 182 (n); 15 (h); 11 (d) | .001 |
| 3rd Ventricle (mm) | 2.8 ± 0.9 | 5.5 ± 3.3 | 4.1 ± 2.8 | .001 |
Note:—Avg indicates average; tr, transverse diameter; ap, anteroposterior diameter; cc, craniocaudal diameter; CC, corpus callosum; Splen, splenium; AC, anterior commissure; n, normal; T, thick; t, thin; a/s, anterior/superior quadrant of 3rd ventricle; a/i, anterior-inferior; p/s, posterior-superior; p/i, posterior-inferior; all, all quadrants; h, hypoplastic; h/d, hypogenetic ± dysgenetic; d, dysgenetic/dysplastic; c, cavum; a, absent; IHA, interhypothalamic adhesion; u, under-rotated; mts, hippocampal sclerosis; f, female.