Associations between preoperative MR imaging metrics and overall survival per LGG molecular subtype, after adjustment for patient age, sex, tumor grade, and surgical resection statusa
| Relative Comparison (Non-Reference:Reference)b | IDHmut-Codel | IDHmut-Noncodel | IDHwt |
|---|---|---|---|
| Tumor size (3rd to 1st quartile) | 2.85 (1.06–7.70) (P = .039) | 2.90 (1.54–5.48) (P < .001) | 3.82 (1.94–7.75) (P < .001) |
| Location (central:peripheral) | 0.59 (0.16–2.18) (P = .430) | 0.50 (0.22–1.17) (P = .101) | 0.78 (0.36–1.70) (P = .534) |
| No. of involved lobes (X + 1:X) | 1.37 (0.84–2.23) (P = .211) | 1.25 (0.99–1.58) (P = .065) | 1.70 (1.28–2.27) (P = .001) |
| Corpus callosum extension (yes:no) | 2.60 (0.69–9.84) (P = .160) | 1.42 (0.59–3.41) (P = .433) | 1.89 (0.78–4.58) (P = .160) |
| Hydrocephalus (yes:no) | 2.57 (0.42–15.81) (P = .308) | 0.63 (0.19–2.11) (P = .457) | 4.43 (1.12–17.54) (P = .034) |
| Midline shift (3rd to 1st quartile) | 1.32 (0.77–2.26) (P = .320) | 1.14 (0.54–2.41) (P = .730) | 1.16 (1.03–1.30) (P = .013) |
| Eloquent cortex (yes:no) | 1.00 (0.29–3.43) (P = .740) | 1.91 (0.77–4.78) (P = .165) | 2.01 (0.90–4.49) (P = .087) |
| Ependymal extension (yes:no) | 6.34 (1.07–37.59) (P = .042) | 1.72 (0.64–4.64) (P = .289) | 1.51 (0.52–4.35) (P = .447) |
| Margins (global test P value)c | (P = .775) | (P = .190) | (P = .031) |
| 33%–66%:<33%d | 1.57 (0.42–5.97) (P = .505) | 0.51 (0.19–1.33) (P = .166) | 0.39 (0.17–0.90) (P = .027) |
| >66%:<33%d | 0.98 (0.09–10.85) (P = .985) | 0.39 (0.13–1.19) (P = .098) | 0.24 (0.06–1.05) (P = .057) |
| >66%:33%–66%d | 0.62 (0.06–6.40) (P = .688) | 0.77 (0.24–2.38) (P = .646) | 0.63 (0.14–2.87) (P = .554) |
| Contrast enhancement (yes:no) | 3.11 (0.71–13.68) (P = .132) | 1.67 (0.62–4.51) (P = .313) | 0.34 (0.13–0.90) (P = .030) |
| Necrosis (yes:no) | 1.84 (0.32–10.78) (P = .498) | 0.28 (0.03–2.42) (P = .247) | 1.93 (0.82–4.58) (P = .134) |
↵a Data are listed as adjusted hazard ratios (95% confidence interval) and corresponding P values.
↵b Relative comparison (nonreference:reference) identifies the nonreference predictor variable value/level and the reference predictor variable value/level at which the adjusted instantaneous risk of death ratio (ie, hazard ratio) was evaluated. For example (3rd:1st quartile) represents a comparison of the adjusted instantaneous risk of death (ie, hazard) between 2 patients, 1 patient whose predictor variable value is at the 3rd quartile of the predictor variable empiric distribution (nonreference) and 1 patient whose predictor variable value is at the 1st quartile of the predictor variable empiric distribution (reference). A relative comparison denoted as (X + 1:1) represents a comparison of the adjusted instantaneous risk of death (ie, hazard) between 2 patients, 1 patient whose predictor variable value is X + 1 units (nonreference) and 1 patient whose predictor variable value is X units (reference). A relative comparison, denoted as (yes:no), represents a comparison of the adjusted instantaneous risk of death (ie, hazard) between 2 patients, 1 patient who has the factor of interest (nonreference = yes) and 1 patient who does not have the factor of interest (reference = no). Note, if the adjusted hazard ratio is >1 (<1), it indicates that the estimate for the instantaneous risk of death is greater (less) for the patient who has the nonreference predictor value/level.
↵c Global test P value is the P value for testing the null hypothesis that the instantaneous risk of death is same for all “margin” categories.
↵d Percentage of LGGs displaying sharp/circumscribed margin.