Table 4:

Studies investigating the relationship between pretreatment ADC and outcome after chemoradiation therapy in head and neck cancer

ReferenceYear of PublicationNo. of PatientsNo. of Patients with OPSCCHPV Status AvailableHigh ADC Associated with
Kim et al1520093322NPoor outcome
Hatakenaka et al1620115722NPoor outcome
Ohnishi et al1720116430NPoor outcome
Srinivasan et al1820122011NPoor outcome
Nakajo et al192012268NBetter outcome
King et al2020133714NPoor outcome
Chawla et al212013329NPoor outcome
Lambrecht et al22201416185NPoor outcome
Ng et al2320166937NPoor outcome
Noij et al2420157840NPoor outcome
Preda et al2520165711NaPoor outcome
Marzi et al2620173414N/YbPoor outcome
Lombardi et al2720174719NPoor outcome
Martens et al28201913496YPoor outcomec

  • Note:—N indicates no; Y, yes.

  • ↵a Minimum ADC value within the ROI.

  • ↵b Only for the small cohort of patients with OPSCC.

  • ↵c Maximum ADC value within the ROI.