Sensitivity, specificity, positive predictive value, and negative predictive value of lesions in isolation^{^a} for BSID-III outcomes

Lesion^{^b}	Abnormal Motor Outcome				Abnormal Cognitive Outcome				Abnormal Language Outcome
Lesion^{^b}	SENS	SPEC	PPV	NPV	SENS	SPEC	PPV	NPV	SENS	SPEC	PPV	NPV
Any lesion present (n = 363)	90	26	17	94	82	26	25	83	78	25	37	66
GMH–IVH (n = 54)	63	72	22	94	41	70	24	83	37	71	43	66
Cerebellar hemorrhage <5 mm (n = 112)	67	52	13	94	56	52	21	83	50	51	35	66
Cerebellar hemorrhage >5 mm (n = 7)	–	–	–	–	5	94	14	83	3	93	14	66
Subependymal cysts (n = 133)	68	47	11	94	64	49	25	83	59	49	42	66
HPI (n = 15)	56	95	60	94	32	94	60	83	19	93	60	66
PVL (n = 13)	65	100	100	94	37	98	85	83	15	93	54	66
Minor unclassified (n = 13)	–	–	–	–	14	91	23	83	13	92	46	66
Major unclassified (n = 8)	36	96	50	94	17	96	50	83	9	95	50	66
Abnormal myelin (n = 47)	38	95	55	90	24	94	55	81	14	92	51	65

Note:—SENS indicates sensitivity; SPEC, specificity; PPV, positive predictive value; NPV, negative predictive value; –, no cases.
↵a “Isolated” implies major lesions excluded; there may be concurrent minor lesions.
↵b Statistics are calculated with respect to the group with no focal lesion.