Patient demographics of internal and external cohorts

	Internal Cohort (n = 598)			External Cohort (n = 143)
	GBM (n = 382)	Metastasis (n = 216)	P Value	GBM (n = 100)	Metastasis (n = 43)	P Value
Age (years)^{^a}	57.3 ± 15.2	57.5 ± 13.8	.808	57.2 ± 12.8	61.0 ± 10.2	.081
Male sex (%)	223 (58.4)	134 (62.0)	.381	63 (62.4)	25 (56.8)	.633
Supratentorial location (%)	369 (96.9)	167 (77.3)	<.001	98 (97.0)	32 (72.7)	<.001
Primary tumor (%)	—	Lung 91 (42.1)	—	—	Lung 20 (45.5)	—
		Breast 25 (11.6)			Breast 6 (13.6)
		GI^{^b} 46 (21.3)			GI^{^b} 7 (15.9)
		GU^{^c} 16 (7.4)			GU^{^c} 7 (15.9)
		Others^{^d} 38 (17.6)			Others^{^d} 3 (6.8)

↵a Mean ± SD.
↵b Gastrointestinal (GI) origin includes tumors of colorectal, esophageal, stomach, and hepatic origin.
↵c Genitourinary (GU) origin includes tumors of kidney, ovary, and cervix origin.
↵d Other origin includes melanoma, head and neck, sarcoma, and unknown primary origin.