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This retrospective observational study is a longitudinal analysis of the neuroimaging pattern of single large-scale mitochondrial deletion syndrome, which is often classified into 3 major clinical syndromes: Kearns-Sayre syndrome, chronic progressive external ophthalmoplegia, and Pearson syndrome. Early findings typically involve the brainstem and basal ganglia with the supratentorial subcortical white matter changes and spinal cord involvement as the disease progresses.

This observational study compared the acquisition time, image quality, diagnostic confidence, and lesion detection rates among sagittal T2WI, standard DIR, and DL-reconstructed DIR in patients with inflammatory myelopathies. It was found that DL-reconstructed DIR significantly reduced acquisition time and improved image quality. DL-reconstructed DIR also improved lesion detection, showing superior diagnostic performance in inflammatory myelopathies without compromising diagnostic confidence.