- Alzheimer Disease Anti-Amyloid Immunotherapies: Imaging Recommendations and Practice Considerations for Monitoring of Amyloid-Related Imaging Abnormalities
This review discusses the 3 key MRI sequences for ARIA monitoring and standardized imaging protocols and provides imaging recommendations for 3 key patient scenarios. All patients on anti-amyloid immunotherapy should have T2* gradient-recalled echo (to evaluate for ARIA-H), 2D or 3D T2 FLAIR (to evaluate for ARIA-E), and DWI (to differentiate ARIA-E from acute ischemia). Patient imaging scenarios are 1) baseline dementia diagnosis/treatment enrollment evaluation, 2) asymptomatic ARIA monitoring, and 3) evaluation of the symptomatic patient on anti-amyloid immunotherapy.
- Hemodynamic Characteristics in Ruptured and Unruptured Intracranial Aneurysms: A Prospective Cohort Study Utilizing the AneurysmFlow Tool
A DSA-based flow quantification tool (AneurysmFlow) was used to measure blood flow vectors and velocities after contrast injection. Complex flow patterns were shown to be common in ruptured aneurysms and those with daughter sacs. Lowest mean aneurysm flow amplitude in the dome and daughter sacs indicated pathophysiologic changes linked to rupture. Also, hypertension, bifurcation location, and irregular shape of unruptured aneurysm were found to be independent rupture risk factors.
- “Flow Void Sign”: Flow Artifact on T2-Weighted MRI Can Be an Indicator of Dural Defect Location in Ventral Type 1 Spinal CSF Leaks
Type 1 CSF leaks are commonly associated with ventral predominant epidural fluid. On 2D T2-weighted and STIR images, CSF-flow artifact in the anterior subarachnoid space and/or the adjacent epidural fluid collection at the level of the dural defect is caused by CSF-flow and may permit accurate prediction of the site of the CSF leak noninvasively.
- A Neuroradiologist’s Guide to Operationalizing the Response Assessment in Neuro-Oncology (RANO) Criteria Version 2.0 for Gliomas in Adults
This article is an overview of the updated version of the RANO 2.0 criteria, which are a standardized determination of radiographic response in adult gliomas on clinical trials. It provides guidance on the criteria for high- and low-grade gliomas in adults, use of the postradiotherapy MRI scan as the baseline for evaluation in newly diagnosed high-grade gliomas, the option of using volumetric tumor measurements, and the removal of subjective nonenhancing tumor evaluations in predominantly enhancing gliomas.
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