- Territory-Related Functional Connectivity Changes Associated with Verbal Memory Decline in Patients with Unilateral Asymptomatic Internal Carotid Stenosis
Fifteen healthy controls, 22 patients with left asymptomatic ICS, and 33 patients with right asymptomatic ICS underwent fMRI, Mini-Mental State Examination, Digit Span Test, and Verbal Learning Tests. Patients with asymptomatic ICS had significant impairment in delayed recall of verbal memory. Patients with left and right asymptomatic ICS showed different patterns of FC alterations in both anterior and posterior circulation territories.
- Diffusion-Weighted Imaging Reveals Impaired Glymphatic Clearance in Idiopathic Intracranial Hypertension
The diffusivity along the cerebral perivascular spaces (DTI-ALPS technique) and lateral association and projection fibers in patients with IIH were compared with normal controls. Using the degree of diffusivity as a surrogate for glymphatic function, IIH patients were shown to have a significantly lower glymphatic clearance compared with controls (P=.005), with a significant association between declining glymphatic clearance and increasing Frisen papilledema grade (P=.046).
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