MY CONTENT

The authors investigated the impact of intracortical lesions on the volumes of subcortical structures (especially the thalamus) compared with other lesions in 71 patients with MS. The volumes of intracortical lesions and white matter lesions were identified on double inversion recovery and FLAIR imaging, respectively, by using 3D Slicer. Volumes of white matter T1 hypointensities and subcortical gray matter, thalamus, caudate, putamen, and pallidum volumes were calculated using FreeSurfer. They conclude that thalamic atrophy was explained better by intracortical lesions than by white matter lesion and T1 hypointensity volumes, especially in patients with more profound disability.