- Multisite Benchmark Study for Standardized Relative CBV in Untreated Brain Metastases Using the DSC-MRI Consensus Acquisition Protocol
This multisite study found that the consensus DSC-MRI acquisition protocol confirmed the utility of standardized rCBV (srCBV) to identify biologically active, treatment-naïve brain metastases as distinguished from normal-appearing white matter and GBM. The data demonstrated that brain metastases of different primary origins have srCBV values that in general are significantly greater than normal-appearing white matter but significantly lower than srCBV for GBM.
- Gadolinium-Enhanced T2 FLAIR Is an Imaging Biomarker of Radiation Necrosis and Tumor Progression in Patients with Brain Metastases
Distinguishing radiation necrosis from tumor progression after radiation therapy for brain metastases is challenging on conventional MRI. This study demonstrated higher normalized contrast-enhanced T1 and T2 FLAIR signal intensity for RN. Contrast-enhanced T2 FLAIR signal intensity distinguished RN and TP with an AUC similar to that of DSC perfusion.
- A Neuroradiologist’s Guide to Operationalizing the Response Assessment in Neuro-Oncology (RANO) Criteria Version 2.0 for Gliomas in Adults
This article is an overview of the updated version of the RANO 2.0 criteria, which are a standardized determination of radiographic response in adult gliomas on clinical trials. It provides guidance on the criteria for high- and low-grade gliomas in adults, use of the postradiotherapy MRI scan as the baseline for evaluation in newly diagnosed high-grade gliomas, the option of using volumetric tumor measurements, and the removal of subjective nonenhancing tumor evaluations in predominantly enhancing gliomas.
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