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In this cross-sectional study, SARS-CoV-2 infection effects on GM/WM volume, WM microstructure, cognitive performance, and peripheral cytokine concentrations were investigated. The study found that the NeuroPASC group had larger global and regional (prefrontal cortex and hippocampus) cerebral WM volume, more self-reported PASC symptoms, more headaches, lower psychometric performance, widespread higher mean kurtosis in WM microstructure, and different cytokine concentration profiles compared with controls. The authors conclude that immune dysregulation following SARS-CoV-2 infection might result in cerebral WM macrostructural and microstructural injury causing NeuroPASC clinical signs and symptoms.

This article is an overview of the updated version of the RANO 2.0 criteria, which are a standardized determination of radiographic response in adult gliomas on clinical trials. It provides guidance on the criteria for high- and low-grade gliomas in adults, use of the postradiotherapy MRI scan as the baseline for evaluation in newly diagnosed high-grade gliomas, the option of using volumetric tumor measurements, and the removal of subjective nonenhancing tumor evaluations in predominantly enhancing gliomas.