- Cough-Associated Changes in CSF Flow in Chiari I Malformation Evaluated by Real-Time MRI
Eight symptomatic patients with Chiari I malformation and 6 healthy participants were studied by using MR pencil beam imaging with a temporal resolution of 50 ms. Patients and healthy participants were scanned in real-time during resting, coughing, and postcoughing periods. CSF flow waveform amplitude, CSF stroke volume, and CSF flow rate were compared between the patients and the control population. Real-time MR imaging noninvasively showed a transient decrease in CSF flow across the foramen magnum after coughing in symptomatic patients with Chiari I malformation.