ROC curve analysis for ischemic core regions (ADC ≤ 620)

	All	Onset-to-Imaging Time
	All	<180 Min (n = 33)	180–360 Min (n = 21)	>360 Min (n = 12)
rCBF
AUC (95% CI)	0.89 (0.86–0.91)	0.85 (0.79–0.89)^{^a}	0.90 (0.85–0.93)^{^a}	0.97 (0.93–0.98)
Best thresholds	0.60	0.72	0.60	0.48
Sensitivity	0.84	0.91	0.92	0.97
Specificity	0.78	0.62	0.79	0.88
rCBV
AUC (95% CI)	0.85 (0.81–0.88)	0.76 (0.70–0.81)^{^a}^,^{^b}	0.87 (0.82–0.91)^{^a}	0.97 (0.92–0.99)
Best thresholds	0.74	0.74	0.77	0.37
Sensitivity	0.82	0.72	0.90	0.91
Specificity	0.75	0.72	0.75	0.97
MTT
AUC (95% CI)	0.49 (0.43–0.54)	0.55 (0.47–0.62)	0.53 (0.43–0.62)	0.62 (0.48–0.74)
Best thresholds	NS	NS	NS	NS
Sensitivity	NS	NS	NS	NS
Specificity	NS	NS	NS	NS
Tmax
AUC (95% CI)	0.85 (0.81–0.88)	0.82 (0.76–0.87)^{^a}	0.79 (0.72–0.85)^{^a}	0.97 (0.92–0.98)
Best thresholds	18.6	18.6	22.2	18.7
Sensitivity	0.80	0.74	0.72	1.00
Specificity	0.82	0.84	0.80	0.89

Note:—NS indicates not significant.
↵a Statistical significance (P < .05), compared with the AUC for >360 minutes.
↵b Statistical significance compared with the AUC for 180–360 minutes.