Abstract
We report a semiautomated postprocessing method based on magnetization transfer MR imaging that can quantify the extent of global disease in patients with multiple sclerosis. The technique combines segmentation and quantitative analysis of imaging data reflecting the structural integrity of white matter. Applications of this technique may include assessment of disease progress and of the efficacy of experimental therapeutic intervention. The height of the histogram peak corresponding to white matter was found to be lowered in patients with multiple sclerosis and the overall distribution of magnetization transfer ratios was shifted to lower values.
- Copyright © American Society of Neuroradiology
In this issue
Jump to section
Related Articles
Cited By...
- Microstructural white matter changes preceding white matter hyperintensities in migraine
- Relation of vision to global and regional brain MRI in multiple sclerosis
- Cognitive decline in AD and mild cognitive impairment is associated with global brain damage
- Global Estimation of Myelination in the Developing Brain on the Basis of Magnetization Transfer Imaging: A Preliminary Study
- Magnetization Transfer Ratio Histogram Analysis of Gray Matter in Relapsing-remitting Multiple Sclerosis
- The effect of gadolinium-enhancing lesions on whole brain atrophy in relapsing-remitting MS
- BRAIN IMAGING
- Serial Analysis of Magnetization-Transfer Histograms and Expanded Disability Status Scale Scores in Patients with Relapsing-Remitting Multiple Sclerosis
- Characterization of White Matter Lesions in Multiple Sclerosis and Traumatic Brain Injury as Revealed by Magnetization Transfer Contour Plots
- Magnetization Transfer Ratio of White Matter Hyperintensities in Subcortical Ischemic Vascular
- Combined Magnetization Transfer and Proton Spectroscopic Imaging in the Assessment of Pathologic Brain Lesions in Multiple
- Characterization of Differences between Multiple Sclerosis and Normal Brain: A Global Magnetization Transfer Application