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Improved Turnaround Times | Median time to first decision: 12 days

Research ArticleBrain

Diffusion-Negative Stroke: A Report of Two Cases

Paul Y-K. Wang, Peter B. Barker, Robert J. Wityk, Aziz M. Uluğ, Peter C. M. van Zijl and Norman J. Beauchamp
American Journal of Neuroradiology November 1999, 20 (10) 1876-1880;
Paul Y-K. Wang
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Peter B. Barker
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Robert J. Wityk
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Aziz M. Uluğ
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Peter C. M. van Zijl
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Norman J. Beauchamp Jr
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    fig 1.

    Case 1: 67-year-old man with word-finding and comprehension difficulties imaged 4 hours (top row) and 4 days (bottom row) after symptom onset. The T2-weighted (T2W), diffusion-weighted (Isotropic DWI), and Dav images were all normal at 4 hours; but at 4 days, the T2-weighted image showed an area of infarction in the left parietal region (arrows).

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    fig 2.

    Case 2: 65 year-old man with mild to moderate aphasia, a slight left-sided facial droop, and minimal left pronator drift scanned 3.5 hours (top row), 13 hours (middle row), and 4 days (bottom row) after symptom onset.

    Top row, Initial T2-weighted (T2W), diffusion-weighted (Isotropic DWI), and Dav images were normal, but the perfusion MR image revealed a large area of delayed flow in the right MCA territory.

    Middle row, At 13 hours, the T2-weighted image remained normal but diffusion-weighted hyperintensity and reduced Dav are now apparent in the right MCA territory.

    Bottom row, T2-weighted image at 4 days revealed hemorrhagic infarction with edema and mild mass effect. The infarct showed decreased Dav at this time, while the perilesional edema had increased Dav.

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    Calculated diffusion constants (Dav) × 10−3 mm2/s (mean ± SD) in 5- × 5-mm regions of eventual infarction (as identified on follow-up MR images) and in contralateral hemisphere

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American Journal of Neuroradiology
Vol. 20, Issue 10
1 Nov 1999
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Cite this article
Paul Y-K. Wang, Peter B. Barker, Robert J. Wityk, Aziz M. Uluğ, Peter C. M. van Zijl, Norman J. Beauchamp
Diffusion-Negative Stroke: A Report of Two Cases
American Journal of Neuroradiology Nov 1999, 20 (10) 1876-1880;

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Diffusion-Negative Stroke: A Report of Two Cases
Paul Y-K. Wang, Peter B. Barker, Robert J. Wityk, Aziz M. Uluğ, Peter C. M. van Zijl, Norman J. Beauchamp
American Journal of Neuroradiology Nov 1999, 20 (10) 1876-1880;
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Cited By...

  • Guidelines for the Early Management of Patients With Acute Ischemic Stroke: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association
  • Ischemic Cerebral Damage: An Appraisal of Synaptic Failure
  • Recommendations for Imaging of Acute Ischemic Stroke: A Scientific Statement From the American Heart Association
  • The clinical significance of diffusion-weighted MR imaging in infratentorial strokes
  • Guidelines and Recommendations for Perfusion Imaging in Cerebral Ischemia: A Scientific Statement for Healthcare Professionals by the Writing Group on Perfusion Imaging, From the Council on Cardiovascular Radiology of the American Heart Association
  • Quantification of Perfusion Using Bolus Tracking Magnetic Resonance Imaging in Stroke: Assumptions, Limitations, and Potential Implications for Clinical Use
  • Benefits of Perfusion MR Imaging Relative to Diffusion MR Imaging in the Diagnosis and Treatment of Hyperacute Stroke
  • Arterial Hyperintensity on Fast Fluid-attenuated Inversion Recovery Images: A Subtle Finding for Hyperacute Stroke Undetected by Diffusion-weighted MR Imaging
  • Systematic Review of Diffusion and Perfusion Imaging in Acute Ischemic Stroke
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