Skip to main content
Advertisement

Main menu

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home

User menu

  • Alerts
  • Log in

Search

  • Advanced search
American Journal of Neuroradiology
American Journal of Neuroradiology

American Journal of Neuroradiology

ASHNR American Society of Functional Neuroradiology ASHNR American Society of Pediatric Neuroradiology ASSR
  • Alerts
  • Log in

Advanced Search

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home
  • Follow AJNR on Twitter
  • Visit AJNR on Facebook
  • Follow AJNR on Instagram
  • Join AJNR on LinkedIn
  • RSS Feeds

AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticleBRAIN

Histopathologic Correlates of Temporal Diffusion Changes in a Rat Model of Cerebral Hypoxia/Ischemia

Naoyuki Miyasaka, Tsukasa Nagaoka, Toshihiko Kuroiwa, Hideaki Akimoto, Tomoko Haku, Toshiro Kubota and Takeshi Aso
American Journal of Neuroradiology January 2000, 21 (1) 60-66;
Naoyuki Miyasaka
aFrom the Departments of Obstetrics and Gynecology (N.M., T.H., T.Kub., T.A.), Neurosurgery (T.N., H.A.), and Neuropathology (T.Kur.), School of Medicine, Tokyo Medical and Dental University, Japan.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Tsukasa Nagaoka
aFrom the Departments of Obstetrics and Gynecology (N.M., T.H., T.Kub., T.A.), Neurosurgery (T.N., H.A.), and Neuropathology (T.Kur.), School of Medicine, Tokyo Medical and Dental University, Japan.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Toshihiko Kuroiwa
aFrom the Departments of Obstetrics and Gynecology (N.M., T.H., T.Kub., T.A.), Neurosurgery (T.N., H.A.), and Neuropathology (T.Kur.), School of Medicine, Tokyo Medical and Dental University, Japan.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Hideaki Akimoto
aFrom the Departments of Obstetrics and Gynecology (N.M., T.H., T.Kub., T.A.), Neurosurgery (T.N., H.A.), and Neuropathology (T.Kur.), School of Medicine, Tokyo Medical and Dental University, Japan.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Tomoko Haku
aFrom the Departments of Obstetrics and Gynecology (N.M., T.H., T.Kub., T.A.), Neurosurgery (T.N., H.A.), and Neuropathology (T.Kur.), School of Medicine, Tokyo Medical and Dental University, Japan.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Toshiro Kubota
aFrom the Departments of Obstetrics and Gynecology (N.M., T.H., T.Kub., T.A.), Neurosurgery (T.N., H.A.), and Neuropathology (T.Kur.), School of Medicine, Tokyo Medical and Dental University, Japan.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Takeshi Aso
aFrom the Departments of Obstetrics and Gynecology (N.M., T.H., T.Kub., T.A.), Neurosurgery (T.N., H.A.), and Neuropathology (T.Kur.), School of Medicine, Tokyo Medical and Dental University, Japan.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • Responses
  • References
  • PDF
Loading

Article Figures & Data

Figures

  • Tables
  • Figure1
    • Download figure
    • Open in new tab
    • Download powerpoint

    fig. 1. A–F, T2-weighted images (A and E) and ADC maps (B, C, D, F) of a representative rat (group C-1) that showed the transient ADC reduction pattern. T2-weighted images show no abnormal signal intensity at any time. A, before the hypoxic/ischemic insult; E, 48 hours after the insult. ADC maps show no ADC change before the hypoxic/ischemic insult (B), acute ADC reduction in the ipsilateral parietal cortex during the insult (C), ADC recovery 60 minutes after resuscitation (D), and no ADC change 48 hours after the insult (F)

  • Figure2
    • Download figure
    • Open in new tab
    • Download powerpoint

    fig. 2. A–F, T2-weighted images (A and E) and ADC maps (B, C, D, F) of a representative rat (group C-2) that showed the biphasic ADC reduction pattern. T2-weighted images show no abnormal signal intensity before the hypoxic/ischemic insult (A), during the insult, or 60 minutes after resuscitation; they do show high signal intensity in the ipsilateral parietal cortex 48 hours after the insult (E). ADC maps show no ADC change before the hypoxic/ischemic insult (B), acute ADC reduction in the ipsilateral parietal cortex during the insult (C), ADC recovery 60 minutes after resuscitation (D), and secondary ADC reduction in the ipsilateral parietal cortex 48 hours after the insult (F)

  • Figure3
    • Download figure
    • Open in new tab
    • Download powerpoint

    fig. 3. A–H, T2-weighted images (A–D) and ADC maps (E–H) of a representative rat (group C-3) that showed the persistent ADC reduction pattern.

    A–D, T2-weighted images show no abnormal signal intensity before the hypoxic/ischemic insult (A), during the insult (B), or 60 minutes after resuscitation (C); they do show high signal intensity in the ipsilateral parietal cortex 6 hours after the insult (D).

    E–H, ADC maps show no ADC change before the hypoxic/ischemic insult (E), acute ADC reduction in the ipsilateral parietal cortex during the insult (F), and sustained ADC decrease 60 minutes after resuscitation (G) and 6 hours after the insult (H).

  • Figure4
    • Download figure
    • Open in new tab
    • Download powerpoint

    fig. 4. Histopathologic findings of the ipsilateral parietal cortices of the control and experimental rats (H and E, original magnification ×400).

    A, Light micrograph of a parietal cortex section from a control rat (group A) shows intact neurons (arrowheads) and well-preserved cell density 48 hours after CCA ligation.

    B, Light micrograph of a parietal cortex section from a rat with the transient ADC reduction pattern (group C-1) shows neuronal loss with ischemic changes (cytoplasmic eosinophilia and pyknotic nuclei, arrows) 48 hours after the hypoxic/ischemic insult.

    C, Light micrograph of a parietal cortex section from a rat with the biphasic ADC reduction pattern (group C-2) shows pan-cellular necrosis, indicative of cerebral infarction, 48 hours after the hypoxic/ischemic insult.

    D, Light micrograph of a parietal cortex section from a rat with the persistent ADC reduction pattern (group C-3) shows cerebral infarction with extensive neuronal pyknosis (thick arrows) and severe neuropilar microvacuolation (thin arrow) 6 hours after the hypoxic/ischemic insult.

Tables

  • Figures
  • Table1

    Time course of ADC changes and histopathologic findings in the ipsilateral parietal cortex in a rat model of hypoxia/ishemia

PreviousNext
Back to top

In this issue

American Journal of Neuroradiology
Vol. 21, Issue 1
1 Jan 2000
  • Table of Contents
  • Index by author
Advertisement
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on American Journal of Neuroradiology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Histopathologic Correlates of Temporal Diffusion Changes in a Rat Model of Cerebral Hypoxia/Ischemia
(Your Name) has sent you a message from American Journal of Neuroradiology
(Your Name) thought you would like to see the American Journal of Neuroradiology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Cite this article
Naoyuki Miyasaka, Tsukasa Nagaoka, Toshihiko Kuroiwa, Hideaki Akimoto, Tomoko Haku, Toshiro Kubota, Takeshi Aso
Histopathologic Correlates of Temporal Diffusion Changes in a Rat Model of Cerebral Hypoxia/Ischemia
American Journal of Neuroradiology Jan 2000, 21 (1) 60-66;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
0 Responses
Respond to this article
Share
Bookmark this article
Histopathologic Correlates of Temporal Diffusion Changes in a Rat Model of Cerebral Hypoxia/Ischemia
Naoyuki Miyasaka, Tsukasa Nagaoka, Toshihiko Kuroiwa, Hideaki Akimoto, Tomoko Haku, Toshiro Kubota, Takeshi Aso
American Journal of Neuroradiology Jan 2000, 21 (1) 60-66;
del.icio.us logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Methods
    • Results
    • Discussion
    • Conclusion
    • Acknowledgments
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • Responses
  • References
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • Motor Deficits Are Triggered by Reperfusion-Reoxygenation Injury as Diagnosed by MRI and by a Mechanism Involving Oxidants
  • Transient Global Amnesia: Diffusion-Weighted Imaging Lesions and Cerebrovascular Disease
  • Predictors of Hemorrhagic Transformation After Intravenous Recombinant Tissue Plasminogen Activator: Prognostic Value of the Initial Apparent Diffusion Coefficient and Diffusion-Weighted Lesion Volume
  • Proton Spectroscopy and Diffusion Imaging on the First Day of Life after Perinatal Asphyxia: Preliminary Report
  • Vasospasm After Subarachnoid Hemorrhage: Interest in Diffusion-Weighted MR Imaging
  • Direct, Longitudinal Comparison of 1H and 23Na MRI After Transient Focal Cerebral Ischemia
  • Crossref
  • Google Scholar

This article has not yet been cited by articles in journals that are participating in Crossref Cited-by Linking.

More in this TOC Section

  • White Matter Alterations in the Brains of Patients with Active, Remitted, and Cured Cushing Syndrome: A DTI Study
  • Qualitative and Quantitative Analysis of MR Imaging Findings in Patients with Middle Cerebral Artery Stroke Implanted with Mesenchymal Stem Cells
  • Fast Contrast-Enhanced 4D MRA and 4D Flow MRI Using Constrained Reconstruction (HYPRFlow): Potential Applications for Brain Arteriovenous Malformations
Show more Brain

Similar Articles

Advertisement

Indexed Content

  • Current Issue
  • Accepted Manuscripts
  • Article Preview
  • Past Issues
  • Editorials
  • Editor's Choice
  • Fellows' Journal Club
  • Letters to the Editor
  • Video Articles

Cases

  • Case Collection
  • Archive - Case of the Week
  • Archive - Case of the Month
  • Archive - Classic Case

More from AJNR

  • Trainee Corner
  • Imaging Protocols
  • MRI Safety Corner
  • Book Reviews

Multimedia

  • AJNR Podcasts
  • AJNR Scantastics

Resources

  • Turnaround Time
  • Submit a Manuscript
  • Submit a Video Article
  • Submit an eLetter to the Editor/Response
  • Manuscript Submission Guidelines
  • Statistical Tips
  • Fast Publishing of Accepted Manuscripts
  • Graphical Abstract Preparation
  • Imaging Protocol Submission
  • Evidence-Based Medicine Level Guide
  • Publishing Checklists
  • Author Policies
  • Become a Reviewer/Academy of Reviewers
  • News and Updates

About Us

  • About AJNR
  • Editorial Board
  • Editorial Board Alumni
  • Alerts
  • Permissions
  • Not an AJNR Subscriber? Join Now
  • Advertise with Us
  • Librarian Resources
  • Feedback
  • Terms and Conditions
  • AJNR Editorial Board Alumni

American Society of Neuroradiology

  • Not an ASNR Member? Join Now

© 2025 by the American Society of Neuroradiology All rights, including for text and data mining, AI training, and similar technologies, are reserved.
Print ISSN: 0195-6108 Online ISSN: 1936-959X

Powered by HighWire