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AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticleBrain

Proton MR Spectroscopy and Preoperative Diagnostic Accuracy: An Evaluation of Intracranial Mass Lesions Characterized by Stereotactic Biopsy Findings

Isabella Maria Burtscher, Gunnar Skagerberg, Bo Geijer, Elisabet Englund, Freddy Ståhlberg and Stig Holtås
American Journal of Neuroradiology January 2000, 21 (1) 84-93;
Isabella Maria Burtscher
aFrom the Departments of Radiology (I.M.B., B.G., F.S., S.H.), Neurosurgery (G.S.), Pathology (E.E.), and Radiation Physics (F.S.), University Hospital, Lund, Sweden.
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Gunnar Skagerberg
aFrom the Departments of Radiology (I.M.B., B.G., F.S., S.H.), Neurosurgery (G.S.), Pathology (E.E.), and Radiation Physics (F.S.), University Hospital, Lund, Sweden.
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Bo Geijer
aFrom the Departments of Radiology (I.M.B., B.G., F.S., S.H.), Neurosurgery (G.S.), Pathology (E.E.), and Radiation Physics (F.S.), University Hospital, Lund, Sweden.
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Elisabet Englund
aFrom the Departments of Radiology (I.M.B., B.G., F.S., S.H.), Neurosurgery (G.S.), Pathology (E.E.), and Radiation Physics (F.S.), University Hospital, Lund, Sweden.
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Freddy Ståhlberg
aFrom the Departments of Radiology (I.M.B., B.G., F.S., S.H.), Neurosurgery (G.S.), Pathology (E.E.), and Radiation Physics (F.S.), University Hospital, Lund, Sweden.
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Stig Holtås
aFrom the Departments of Radiology (I.M.B., B.G., F.S., S.H.), Neurosurgery (G.S.), Pathology (E.E.), and Radiation Physics (F.S.), University Hospital, Lund, Sweden.
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    fig 1.

    A–G, Patient with a pineocytoma: six MR spectra (A–F) represent voxels outlined on the axial, contrast-enhanced T1-weighted MR image (G). Only voxels covering contrast-enhancing parts of the lesion showed pathologic MR spectra.

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    fig 2.

    ←A–Q, Patient with a cystic high-grade glioma: the images show the heterogeneity of spectra across the lesion. A is an axial, contrast-enhanced T1-weighted MR image with the measurement area and voxels represented by the MR spectra in B–Q outlined; B–I represent voxels in the vertical row (top to bottom) and (J–Q) represent voxels in the horizontal row (left to right). The spectrum representing the intersection of the vertical and horizontal rows is shown twice (H and P)

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    fig 2.

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    fig 3.

    Scattergram of signal ratios in stereotactic biopsy target points for different tumor types. LA = low-grade astrocytoma (n = 4), HA = high-grade astrocytoma (n = 11), LY = lymphoma (n = 3)

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    fig 4.

    MR spectroscopic scout images and corresponding spectra represent the stereotactic biopsy target points in a high-grade (A and B) and a low-grade (C and D) astrocytoma. The two spectra are almost identical, and signal ratios could not be used to grade the tumors

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    TABLE 1:

    List of histopathologic diagnoses

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    TABLE 2:

    Distribution Pattern of pathologic spectra

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    TABLE 3:

    Signal ratios in neuroradiologically normal-appearing tissue and in the stereotactic target point (mean ± SD)

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    TABLE 4:

    Influence of MR spectroscopy on diagnostic accuracy as compared with neuroradiologic diagnosis based on distribution pattern of pathologic spectra

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    TABLE 5:

    Number of cases with true, histopathologically verified diagnoses for the different observers and different ranks

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American Journal of Neuroradiology
Vol. 21, Issue 1
1 Jan 2000
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Cite this article
Isabella Maria Burtscher, Gunnar Skagerberg, Bo Geijer, Elisabet Englund, Freddy Ståhlberg, Stig Holtås
Proton MR Spectroscopy and Preoperative Diagnostic Accuracy: An Evaluation of Intracranial Mass Lesions Characterized by Stereotactic Biopsy Findings
American Journal of Neuroradiology Jan 2000, 21 (1) 84-93;

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Proton MR Spectroscopy and Preoperative Diagnostic Accuracy: An Evaluation of Intracranial Mass Lesions Characterized by Stereotactic Biopsy Findings
Isabella Maria Burtscher, Gunnar Skagerberg, Bo Geijer, Elisabet Englund, Freddy Ståhlberg, Stig Holtås
American Journal of Neuroradiology Jan 2000, 21 (1) 84-93;
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  • Metabolic profile of PML lesions in patients with and without IRIS: An observational study
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  • Diagnostic performance of spectroscopic and perfusion MRI for distinction of brain tumors
  • Physiologic and Metabolic Magnetic Resonance Imaging in Gliomas
  • Preliminary Assessment of Turbo Spectroscopic Imaging for Targeting in Brain Biopsy
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