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Research ArticleBrain

Diffusion Tensor MR Imaging of the Brain: Effect of Diffusion Weighting on Trace and Anisotropy Measurements

Elias R. Melhem, Ryuta Itoh, Lisa Jones and Peter B. Barker
American Journal of Neuroradiology November 2000, 21 (10) 1813-1820;
Elias R. Melhem
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Ryuta Itoh
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Lisa Jones
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Peter B. Barker
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    fig 1.

    Axial ADCi, FA, and eigenvalue maps.

    A, ROI used in data analysis are superimposed on axial ADCi map and FA map calculated at the level of the basal ganglia. 1, left putamen; 2, right putamen; 3, genu of corpus callosum; 4, splenium of the corpus callosum. ROI were also placed in the pons and centrum semiovale (not shown). The location and size of the ROI varied across participants and hemispheres but was kept fixed across the different maps.

    B, Axial calculated eigenvalue maps (λ1, λ2, λ3) at the level of the basal ganglia.

  • fig 2.
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    fig 2.

    Signal decay versus b value obtained from diffusion-weighted (six directions) MR images of a water phantom. The monoexponential decay indicates minimal influence of experimental/systemic errors on measurements

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    fig 3.

    Graph of the average ADCi for the different number of b values, obtained from the right centrum semiovale, shows a significant difference between the b0b1 group and the remaining four groups.

    fig 4. Graph of the average ADCi for the different strengths of b values, obtained from the right centrum semiovale, shows a significant difference between all the groups except b0b4 and b0b5.

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    fig 5.

    Graph of the average SD of ADCi for the different strengths of b values, obtained from the splenium of the corpus callosum, shows a significant difference between the b0b1 group and the remaining four groups.

    fig 6. Graph of the average SD of FA for the different strengths of b values, obtained from the splenium of the corpus callosum, shows a significant difference between the b0b1 group and the remaining four groups.

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    TABLE 1:

    Nine combinations of the b values used to calculate the ADCi, FA, E0, E1, and E2 maps

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    TABLE 2:

    Measured values of average ADCi and FA obtained from maps generated using all 6 b values

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    TABLE 3:

    ANOVA for ADCi, FA, and their respective SD for the subgroups with different number of b values

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    TABLE 4:

    ANOVA for ADCi, FA and their respective SD for the subgroups with different strengths of b values

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American Journal of Neuroradiology
Vol. 21, Issue 10
1 Nov 2000
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Cite this article
Elias R. Melhem, Ryuta Itoh, Lisa Jones, Peter B. Barker
Diffusion Tensor MR Imaging of the Brain: Effect of Diffusion Weighting on Trace and Anisotropy Measurements
American Journal of Neuroradiology Nov 2000, 21 (10) 1813-1820;

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Diffusion Tensor MR Imaging of the Brain: Effect of Diffusion Weighting on Trace and Anisotropy Measurements
Elias R. Melhem, Ryuta Itoh, Lisa Jones, Peter B. Barker
American Journal of Neuroradiology Nov 2000, 21 (10) 1813-1820;
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