Article Figures & Data
Figures
- fig 1.
A and B, Axial T1-weighted images show placement of voxel in the left frontal lobe (A) and in the left temporal lobe (B)
- fig 2.
MR spectra from the frontal lobes.
A, Proton spectra from the left frontal lobe in a control subject show normal metabolites. C, choline; Cr, creatine; N, NAA.
B, Proton spectra from the left frontal lobe in a patient with BPAD show prominent resonances between 2.1 and 2.5 ppm, corresponding to Glu/Gln (G). The resonances between 0.8 and 1.8 ppm correspond to lipids (L). C, choline; Cr, creatine; N, NAA.
- fig 3.
MR spectra from the temporal lobes.
A, Proton spectra from the left temporal lobe in a control subject show normal metabolites.
B, Proton spectra from the left temporal lobe in a patient with BPAD show prominent Glu/Gln (G) but no lipids. C, choline; Cr, creatine; N, NAA.
- fig 4.
MR spectra from the frontal lobes in a patient with BPAD obtained with smaller voxels.
A, Axial T1-weighted localizer image with grid shows dense. White square outlines the area of analysis. Study was obtained with 2D PRESS technique (TE = 135). Note location of individual voxel (arrow), corresponding to spectra in B.
B, Proton spectra from voxel (arrow, A; 1 × 1 × 1.5 cm) show marked elevation of lipids (L). Note that voxel is far away from any fat-containing structure, precluding extraneous contamination. C, choline; Cr, creatine; N, NAA.
C, Proton spectra of individual voxel placed contralateral and in nearly a mirror position to B still show marked elevation of lipids (L). Again, voxel is placed away from fat-containing structures that could conceivably contaminate it. C, choline; Cr, creatine; N, NAA.
Tables
TABLE 1:Means and SDs on the NEPSY test for children with bipolar affective disorder
- TABLE 2:
Means and SDs for the Woodcock-Johnson Psychoeducational Battery in children with bipolar affective disorder
- TABLE 3:
Metabolite ratios in the frontal lobes of children with bipolar affective disorder (BPAD) (n = 10) and unaffected control subjects (n = 10)
- TABLE 4:
Metabolite ratios in the basal ganglia for children with bipolar affective disorder (BPAD) (n = 10) and unaffected control subjects (n = 10)
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