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AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticlePediatric Neuroimaging

X-linked Adrenoleukodystrophy: The Role of Contrast-enhanced MR Imaging in Predicting Disease Progression

Elias R. Melhem, Daniel J. Loes, Christos S. Georgiades, Gerald V. Raymond and Hugo W. Moser
American Journal of Neuroradiology May 2000, 21 (5) 839-844;
Elias R. Melhem
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Daniel J. Loes
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Christos S. Georgiades
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Gerald V. Raymond
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Hugo W. Moser
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References

  1. Igarashi M, Schaumburg HH, Powers J, et al. Fatty acid abnormality in adrenoleukodystrophy. J Neurochem 1976;26:851-860
    PubMedWeb of Science
  2. Singh I, Moser AB, Goldfischer S, et al. Lignoceric acid is oxidized in the peroxisomes: implications for the Zellweger cerebro-hepato-renal syndrome and adrenoleuko-dystrophy. Proc Natl Acad Sci U S A 1984;81:4203-4207
    Abstract/FREE Full Text
  3. Laxo O, Contreras M, Hashmi M, et al. Peroxisomal lignoceroyl-CoA ligase deficiency in childhood adrenoleukodystrohy and adrenomyeloneuropathy. Proc Natl Acad Sci U S A 1988;85:7647-7651
    Abstract/FREE Full Text
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    Migeon BR, Moser HW, Moser AB, et al. Adrneoleukodystrophy: evidence for X-linkage, inactivation and selection favoring the mutant allele in heterozygous cells. Proc Natl Acad Sci U S A 1981; 78:5066-5070
    Abstract/FREE Full Text
  5. Bezman L, Moser HW. The incidence of X-linked adrenoleukodystrophy and the relative frequency of its phenotypes. Am J Med Genet 1998;76:415-419
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  6. Moser HW. Adrenoleukodystrophy: phenotype, genetics, pathogenesis and therapy. Brain 1997;120:1485-1508
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    Smith KD, Kemp S, Braiterman LT, et al. X-linked adrenoleukodystrophy: genes, mutations, and phenotypes. Neurochem Res 1999;24:511-525
  8. Singh I, Moser AB, Moser HW, et al. Adrenoleukodystrophy: impaired oxidation of VLCF in white blood cells, cultured skin fibroblasts and amniocytes. Pediatr Res 1984;18:286-290
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    Abstract/FREE Full Text
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    Krivit W, Lockman LA, Watkins PA, et al. The future for treatment by bone marrow transplantation for adrenoleukodystrophy, metachromatic leukodystrophy, globid cell leukodystrophy and Hurler syndrome. J Inherit Metab Dis 1995;18:398-412
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American Journal of Neuroradiology
Vol. 21, Issue 5
1 May 2000
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Cite this article
Elias R. Melhem, Daniel J. Loes, Christos S. Georgiades, Gerald V. Raymond, Hugo W. Moser
X-linked Adrenoleukodystrophy: The Role of Contrast-enhanced MR Imaging in Predicting Disease Progression
American Journal of Neuroradiology May 2000, 21 (5) 839-844;

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X-linked Adrenoleukodystrophy: The Role of Contrast-enhanced MR Imaging in Predicting Disease Progression
Elias R. Melhem, Daniel J. Loes, Christos S. Georgiades, Gerald V. Raymond, Hugo W. Moser
American Journal of Neuroradiology May 2000, 21 (5) 839-844;
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  • The brain penetrant PPAR{gamma} agonist leriglitazone restores multiple altered pathways in models of X-linked adrenoleukodystrophy
  • Neurocognitive benchmarks following transplant for emerging cerebral adrenoleukodystrophy
  • Clinical and radiographic course of arrested cerebral adrenoleukodystrophy
  • MRI brain lesions in asymptomatic boys with X-linked adrenoleukodystrophy
  • Childhood Cerebral Adrenoleukodystrophy: MR Perfusion Measurements and Their Use in Predicting Clinical Outcome after Hematopoietic Stem Cell Transplantation
  • Intensity of MRI Gadolinium Enhancement in Cerebral Adrenoleukodystrophy: A Biomarker for Inflammation and Predictor of Outcome following Transplantation in Higher Risk Patients
  • Dramatic worsening of adult-onset X-linked adrenoleukodystrophy after head trauma
  • Magnetization transfer MRI demonstrates spinal cord abnormalities in adrenomyeloneuropathy
  • Assessment of adrenoleukodystrophy lesions by high field MRS in non-sedated pediatric patients
  • Analysis of MRI patterns aids prediction of progression in X-linked adrenoleukodystrophy
  • T2 Relaxation Measurements in X-linked Adrenoleukodystrophy Performed Using Dual-echo Fast Fluid-attenuated Inversion Recovery MR Imaging
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