Serial Proton MR Spectroscopy of Contrast-enhancing Multiple Sclerosis Plaques: Absolute Metabolic Values over 2 Years during a Clinical Pharmacological Study

References

1. ↵
   Van Hecke P, Marchal G, Johannik K, et al. Human brain proton localized NMR spectroscopy in multiple sclerosis. Magn Reson Med 1991;18:199-206

   PubMedWeb of Science
2. ↵
   Grossman RI, Lenkinski RE, Ramer KN, Gonzales-Scarano F, Cohen JA. MR proton spectroscopy in multiple sclerosis. AJNR Am J Neuroradiol 1992;13:1535-1543

   Abstract/FREE Full Text
3. Koopmans RA, Li DKB, Zhu G, Allen PS, Penn A, Paty DW. Magnetic resonance spectroscopy of multiple sclerosis: in-vivo detection of myelin breakdown products. Lancet 1993;341:631-632

   CrossRefPubMedWeb of Science
4. Hiehle JF, Jr, Lenkinski RE, Grossman RI, et al. Correlation of spectroscopy and magnetization transfer imaging in the evaluation of demyelinating lesions and normal appearing white matter in multiple sclerosis. Magn Reson Med 1994;32:285-293

   CrossRefPubMedWeb of Science
5. ↵
   Husted CA, Goodin DS, Hugg JW. Biochemical alterations in multiple sclerosis lesions and normal-appearing white matter detected by in vivo ³¹P and ¹H spectroscopic imaging. Ann Neurol 1994;36:157-165

   CrossRefPubMedWeb of Science
6. Davies SE, Newcombe J, Williams SR, McDonald WI, Clark JB. High resolution proton NMR spectroscopy of multiple sclerosis lesions. J Neurochem 1995;64:742-748

   PubMedWeb of Science
7. Roser W, Hagberg G, Mader I, et al. Proton MRS of gadolinium-enhancing MS plaques and metabolic changes in normal-appearing white matter. Magn Reson Med 1995;33:811-817

   PubMedWeb of Science
8. ↵
   Peters AR, Geele JAG, den Boer JA, Preve RL, Minderhoud JM, ‘s-Gravenmade EJ. A study of multiple sclerosis patients with magnetic resonance spectroscopic imaging. Multiple Sclerosis 1995;1:25-31

   CrossRefPubMed
9. Fu L, Wolfson C, Worsley KJ, et al. Statistics for investigation of multimodal MR imaging data and an application to multiple sclerosis patients. NMR Biomed 1996;9:339-346

   CrossRefPubMedWeb of Science
10. Matthews PM, Pioro E, Narayanan S, et al. Assessment of lesion pathology in multiple sclerosis using quantitative morphometry and magnetic resonance spectroscopy. Brain 1996;119:715-722

    CrossRefPubMedWeb of Science
11. Pan JW, Hetherington HP, Vaughan JT, Mitchell G, Pohost GM, Whitaker JN. Evaluation of multiple sclerosis by 1H spectroscopic imaging at 4.1 T. Magn Reson Med 1996;36:72-77

    PubMedWeb of Science
12. Hirsch JA, Lenkinski RE, Grossman RI. MR spectroscopy in the evaluation of enhancing lesions in the brain in multiple sclerosis. AJNR Am J Neuroradiol 1996;17:1829-1836

    Abstract
13. Tourbah A, Stievenart JL, Iba-Zizen MT, Zannoli G, Lyon-Caen O, Cabanis EA. In vivo localized NMR proton spectroscopy of normal appearing white matter in patients with multiple sclerosis. J Neuroradiol 1996;23:49-55

    PubMedWeb of Science
14. ↵
    Schiepers C, Van Hecke P, Vandenberghe R, et al. Positron emission tomography, magnetic resonance imaging and proton NMR spectroscopy of white matter in multiple sclerosis. Multiple Sclerosis 1997;3:8-17

    CrossRefPubMedWeb of Science
15. ↵
    Davie CA, Barker GJ, Thompson AJ, Tofts PS, McDonald WI, Miller DH. ¹H Magnetic resonance spectroscopy of chronic cerebral white matter lesions and normal appearing white matter in multiple sclerosis. J Neurol Neurosurg Psychiatry 1997;63:736-742

    Abstract/FREE Full Text
16. Rooney WD, Goodkin DE, Schuff N, Meyerhoff DJ, Norman D, Weiner M. ¹H MRSI of normal appearing white matter in multiple sclerosis. Multiple Sclerosis 1997;3:231-327

    CrossRefPubMedWeb of Science
17. Falini A, Calabrese G, Filippi M, et al. Benign versus secondary-progressive multiple sclerosis: the potential role of proton MR spectroscopy in defining the nature of disability. AJNR Am J Neuroradiol 1998;19:223-229

    Abstract
18. ↵
    Larsson HBW, Christiansen P, Jensen M, et al. Localized in vivo proton spectroscopy in the brain of patients with multiple sclerosis. Magn Reson Med 1991;22:23-31

    CrossRefPubMedWeb of Science
19. ↵
    Matthews PM, Francis G, Antel J, Arnold DL. Proton magnetic resonance spectroscopy for metabolic characterization of plaques in multiple sclerosis. Neurology 1991;41:1251-1256

    Abstract/FREE Full Text
20. Bruhn H, Frahm J, Merboldt KD, et al. Multiple sclerosis in children: cerebral metabolic alterations monitored by localized proton magnetic resonance spectroscopy in vivo. Ann Neurol 1992;32:140-150

    CrossRefPubMedWeb of Science
21. Davie CA, Hawkins CP, Barker GJ, et al. Detection of myelin breakdown products by proton magnetic resonance spectroscopy. Lancet 1993;341:630-631

    PubMedWeb of Science
22. Arnold DL, Riess GT, Matthews PM, et al. Use of magnetic resonance spectroscopy for monitoring disease progression in multiple sclerosis. Ann Neurol 1994;36:76-82

    CrossRefPubMedWeb of Science
23. ↵
    Davie CA, Hawkins CP, Barker GJ, et al. Serial proton magnetic resonance spectroscopy in acute multiple sclerosis lesions. Brain 1994;117:49-58

    CrossRefPubMedWeb of Science
24. ↵
    De Stefano N, Matthews PM, Antel JP, Preul M, Francis G, Arnold DL. Chemical pathology of acute demyelinating lesions and its correlation with disability. Ann Neurol 1995;38:901-909

    CrossRefPubMedWeb of Science
25. ↵
    Davie CA, Barker GJ, Webb S, et al. Persistent functional deficit in multiple sclerosis and autosomal dominant cerebellar ataxia is associated with axon loss. Brain 1995;118:1583-1592

    CrossRefPubMedWeb of Science
26. Landtblom AM, Sjoquist L, Soderfeldt B, Nyland H, Thuomas KA. Proton MR spectroscopy and MR imaging in acute and chronic multiple sclerosis: ringlike appearances in acute plaques. Acta Radiol 1996;37:278-287

    PubMedWeb of Science
27. Kimura H, Grossman RI, Lenkinski RE, Gonzales-Scarano F. Proton MR spectroscopy and magnetization transfer ratio in multiple sclerosis: correlative findings of active versus irreversible plaque disease. AJNR Am J Neuroradiol 1996;17:1539-1547

    Abstract
28. De Stefano N, Matthews PM, Narayanan S, Francis GS, Antel JP, Arnold DL. Axonal dysfunction and disability in a relapse of multiple sclerosis: longitudinal study of a patient. Neurology 1997;49:1138-1141

    Abstract/FREE Full Text
29. ↵
    Narayana PA, Doyle TJ, Lai D, Wolinsky JS. Serial proton magnetic resonance spectroscopic imaging, contrast-enhanced magnetic resonance imaging, and quantitative lesion volumetry in multiple sclerosis. Ann Neurol 1998;43:56-71

    CrossRefPubMedWeb of Science
30. Fu L, Matthews PM, De Stefano N, et al. Imaging axonal damage of normal-appearing white matter in multiple sclerosis. Brain 1998;121:103-113

    CrossRefPubMedWeb of Science
31. De Stefano N, Matthews PM, Fu L, et al. Axonal damage correlates with disability in patients with relapsing-remitting multiple sclerosis: results of a longitudinal magnetic resonance spectroscopy study. Brain 1998;121:1469-1477

    CrossRefPubMedWeb of Science
32. ↵
    Sarchielli P, Prescutti O, Tarducci R, et al. ¹H-MRS in patients with multiple sclerosis undergoing treatment with interferon-1α: results of a preliminary study. J Neurol Neurosurg Psychiatry 1998;64:204-212

    Abstract/FREE Full Text
33. ↵
    Kappos L, Radue EW, Dellas S, et al. 15 ± Deoxyspergualin (DSG) in the treatment of active multiple sclerosis: final analysis of the European multicenter study. Neurology 1996;410-411
34. ↵
    Lublin FD, Reingold SC. Defining the clinical course of multiple sclerosis: results of an international survey. Neurology 1996;46:907-911

    Abstract/FREE Full Text
35. ↵
    Poser CM, Paty DW, Scheinberg L, et al. New diagnostic criteria for multiple sclerosis: guidelines for research protocols. Ann Neurol 1983;13:227-231

    CrossRefPubMedWeb of Science
36. ↵
    Kurtzke JF. Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). Neurology 1983;33:1444-1452

    Abstract/FREE Full Text
37. ↵
    Granot J. Selected volume excitation using stimulated echoes (VEST): applications to spatially localized spectroscopy and imaging. J Magn Reson 1986;70:488-492
38. Kimmich R, Hoepfel D. Volume-selective multipulse spin-echo spectroscopy. J Magn Reson 1987;72:379-384
39. Frahm J, Merboldt KD, Hänicke W. Localized proton spectroscopy using stimulated echoes. J Magn Reson 1987;72:502-508

    CrossRefWeb of Science
40. ↵
    Moonen CTW, van Zijl PCM. Highly effective water suppression for in vivo proton NMR spectroscopy (DRYSTEAM). J Magn Reson 1990;88:28-41

    Web of Science
41. ↵
    Klose U. In vivo proton spectroscopy in presence of eddy currents. Magn Reson Med 1990;14:26-30

    CrossRefPubMedWeb of Science
42. Provencher SW. Estimation of metabolite concentrations from localized in vivo proton NMR spectra. Magn Reson Med 1993;30:672-679

    CrossRefPubMedWeb of Science
43. Michaelis T, Merboldt KD, Bruhn H, Hänicke W, Frahm J. Absolute concentrations of metabolites in the adult human brain in vivo: quantification of localized proton MR spectra. Radiology 1993;187:219-227

    CrossRefPubMedWeb of Science
44. ↵
    Roser W, Steinbrich W, Radue EW. Results and consequences of frequent quality controls for quantitative clinical ¹H-MR-spectroscopy. Rofo Fortschr Geb Rontgenstr Neuen Bildgeb Verfahr 1997;166:554-557

    PubMed
45. ↵
    Soher BJ, Hurd RE, Sailasuta N, Barker PB. Quantitation of automated single-voxel proton MRS using cerebral water as an internal reference. Magn Reson Med 1996;36:335-339

    CrossRefPubMedWeb of Science
46. Kwock L, Brown MA, Castillo M. Extraneous lipid contamination in single-volume proton MR spectroscopy: phantom and human studies. AJNR Am J Neuroradiol 1997;18:1349-1357

    Abstract
47. ↵
    Marshall I, Wardlaw J, Cannon J, Slattery J, Sellar RJ. Reproducibility of metabolite peak areas in ¹H MRS of brain. Magn Reson Imaging 1996;14:281-292

    CrossRefPubMedWeb of Science
48. Roser W. Letter to the editor. Magn Reson Imaging 1997;15:381-383

    PubMed
49. ↵
    Simmons A, Smail M, Moore E, Williams SCR. Serial precision of metabolite peak area ratios and water referenced metabolite peak areas in proton MR spectroscopy of the human brain. Magn Reson Imaging 1998;16:319-330

    CrossRefPubMedWeb of Science
50. Frahm J, Bruhn H, Gyngell ML, Merboldt KD, Haenicke W, Sauter R. Localized proton NMR spectroscopy in different regions of the human brain in vivo: relaxation times and concentrations of cerebral metabolites. Magn Reson Med 1989;11:47-63

    CrossRefPubMedWeb of Science
51. Hennig J, Pfister H, Ernst T, Ott D. Direct absolute quantification of metabolites in the human brain with in vivo localized proton spectroscopy. NMR Biomed 1992;5:193-199

    CrossRefPubMedWeb of Science
52. Christiansen P, Henriksen O, Stubgaard M, Gideon P, Larsson HB. In vivo quantification of brain metabolites by ¹H-MRS using water as internal standard. Magn Reson Imaging 1993;11:107-118

    CrossRefPubMedWeb of Science
53. Christiansen P, Toft P, Larsson HB, Stubgaard M, Henriksen O. The concentration of N-acetyl aspartate, creatine + phosphocreatine and choline in different parts of the brain in adulthood and senium. Magn Reson Imaging 1993;11:799-806

    CrossRefPubMedWeb of Science
54. ↵
    Danielsen ER, Henriksen O. Absolute quantitative proton NMR spectroscopy based on the amplitude of the local water suppression pulse: quantification of the brain water and metabolites. NMR Biomed 1994;7:311-318

    PubMed
55. ↵
    Prineas JW, Barnard RO, Kwon EE, Sharer LR, Cho ES. Multiple sclerosis: remyelination of nascent lesions. Ann Neurol 1993;33:137-151

    CrossRefPubMedWeb of Science
56. ↵
    Bitsch A, Bruhn H, Vougioukas V, et al. Inflammatory CNS demyelination: histopathologic correlation with in vivo quantitative proton MR spectroscopy. AJNR Am J Neuroradiol 1999;20:1619-1627

    Abstract/FREE Full Text
57. ↵
    Inglis BA, Brenner RE, Munro PMG, Williams SCR, McDonald WI, Sales KD. Works in progress. Measurement of proton NMR relaxation times for NAA, Cr, and Cho in acute EAE. In: Book of Abstracts of the 11th Annual Meeting of the Society for Magnetic Resonance in Medicine, Berkley, CA, 1992. Society of Magnetic Resonance in Medicine 1992;2162
58. ↵
    Birken DL, Oldendorf WH. N-acetyl-L-aspartic acid: a literature review of a compound prominent in 1H-NMR spectroscopy studies of the brain. Neurosci Biobehav Rev 1989;13:23-31

    CrossRefPubMedWeb of Science
59. ↵
    Burri R, Steffen C, Herschkowitz N. N-acetyl-L-aspartate is a major source of acetyl groups for lipid synthesis during rat brain development. Dev Neurosci 1991;13:403-422

    CrossRefPubMedWeb of Science