In Vivo Detection of Postictal Perturbations of Cerebral Metabolism by Use of Proton MR Spectroscopy: Preliminary Results in a Canine Model of Prolonged Generalized Seizures

References

1. 1.↵
   Merritt HH, Rowland LP. Merritt's Textbook of Neurology. Philadelphia: Lea & Febiger; 1989
2. 2.↵
   Choi DW. Glutamate neurotoxicity and diseases of the nervous system. Neuron 1988;1:623-634

   CrossRefPubMedWeb of Science
3. 3.↵
   Perry TL, Hansen S, Kennedy J, Wada JA, Thompson GB. Amino acids in human epileptogenic foci. Arch Neurol 1975;32:752-754

   CrossRefPubMed
4. 4.↵
   Perry TL, Hansen S. Amino acid abnormalities in epileptogenic brain. Neurology 1981;31:872-876

   Abstract/FREE Full Text
5. 5.
   Petroff OAC, Spencer DD, Alger JR, Prichard JW. High-field proton magnetic resonance spectroscopy. Neurology 1989;39:1197-1202

   Abstract/FREE Full Text
6. 6.↵
   Petroff OAC, Pleban LA, Spencer DD. Symbiosis between in vivo and in vitro NMR spectroscopy: the creatine, N-acetylaspartate, glutamate, and GABA content of the epileptic human brain. Magn Reson Imaging 1995;13:1197-1211

   CrossRefPubMedWeb of Science
7. 7.↵
   Van Gelder NM, Sherwin AL, Rasmussen T. Amino acid content of epileptogenic human brain: focal versus surrounding regions. Brain Res 1972;40:385-393

   CrossRefPubMedWeb of Science
8. 8.↵
   Peeling J, Sutherland G. 1H Magnetic resonance spectroscopy of extracts of human epileptic neocortex and hippocampus. Neurology 1993;43:589-594

   Abstract/FREE Full Text
9. 9.↵
   Sherwin A, Robitaille Y, Quesney F, et al. Excitatory amino acids are elevated in human epileptic cerebral cortex. Neurology 1988;38:920-923

   Abstract/FREE Full Text
10. 10.↵
    Ding R, Asada H, et al. Changes in extracellular glutamate and GABA levels in the hippocampal CA3 and CA1 areas and the induction of glutamic acid decarboxylase-67 in dentate granule cells of rats treated with kainic acid. Brain Res 1998;800:105-113

    CrossRefPubMedWeb of Science
11. 11.
    Rowley HL, Marsden CA, Martin KF Generalized seizure-induced changes in rat hippocampal glutamate but not GABA release are potentiated by repeated seizures. Neurosci Lett 1997;234:143-146

    CrossRefPubMed
12. 12.↵
    Sechi G, Rosati G, Deiana GA, et al. Co-variation of free amino acids in brain interstitial fluid during pentylenetetrazole-induced convulsive status epilepticus. Brain Res 1997;764:230-236

    CrossRefPubMed
13. 13.↵
    Allen IC, Grieve A, et al. Differential changes in the content of amino acid neurotransmitters in discrete regions of the rat brain prior to the onset and during the course of homocysteine-induced seizures. J Neurochem 1986;46:1582-1592

    CrossRefPubMedWeb of Science
14. 14.↵
    Blennow G, Folbergrova J, et al. Cerebral metabolic and circulatory changes in the rat during sustained seizures induced by DL-homocysteine. Brain Res 1979;179:129-146

    CrossRefPubMedWeb of Science
15. 15.↵
    Chapman AG, Meldrum BS, et al. Cerebral metabolic changes during prolonged epileptic seizures in rats. J Neurochem 1977;28:1025-1035

    CrossRefPubMedWeb of Science
16. 16.↵
    Stryer L. Biochemistry. 2nd ed. San Francisco: Freeman; 1981
17. 17.
    Duffy TE, Howse DC, et al. Cerebral energy metabolism during experimental status epilepticus. J Neurochem 1975;24:925-934

    CrossRefPubMedWeb of Science
18. 18.↵
    Petroff OA, Prichard JW, Ogino T, Avison M, Alger JR, Shulman RG. Combined 1H and 31P nuclear magnetic resonance spectroscopic studies of bicuculline-induced seizures in vivo. Ann Neurol 1986;20:185-193

    CrossRefPubMedWeb of Science
19. 19.↵
    Erecinska M, Silver IA. Metabolism and role of glutamate in mammalian brain. Prog Neurobiol 1990;35:245-296

    CrossRefPubMedWeb of Science
20. 20.↵
    Fazekas F, Kapeller P, Schmidt R, et al. Magnetic resonance imaging and spectroscopy findings after focal status epilepticus. Epilepsia 1995;36:946-949

    CrossRefPubMedWeb of Science
21. 21.↵
    Bryan RN. MR spectroscopy of temporal lobe epilepsy: good news and bad news. AJNR Am J Neuroradiol 1998;19:189

    PubMed
22. 22.↵
    Katherman AE. Effects of fentanyl citrate and droperidol on electroencephalographic findings in dogs. Am J Vet Res 1985;46:974-976

    PubMed
23. 23.↵
    Du H, Orii R, et al. Pancuronium increases pulmonary arterial pressure in lung injury. Br J Anaesth 1996;77:526-529

    Abstract/FREE Full Text
24. 24.↵
    Prost RW, Mark L, et al. Detection of glutamate/glutamine resonances by 1H magnetic resonance spectroscopy at 0.5 tesla. Magn Reson Med 1997;37:615-618

    PubMed
25. 25.↵
    Shapiro S, Kubek M, et al. Regional changes in central nervous system thyrotropin-releasing hormone after pentylenetetrazol-induced seizures in dogs. Neurosurgery 1992;31:935-939

    PubMed
26. 26.↵
    Soher BJ, Hurd RE, Sailasuta N, Barker PB. Quantitation of automated single-voxel proton MRS using cerebral water as an internal reference. Magn Reson Med 1996;36:335-339

    PubMedWeb of Science
27. 27.↵
    Roebuck JR, et al. Correction of phase effects produced by eddy currents in solvent-suppressed 1H-CSI. Magn Reson Med 1993;30:277-282

    CrossRefPubMedWeb of Science
28. 28.↵
    Christiansen P, Toft P, Larsson HBW, Stubgaard M, Henriksen O. The concentration of N-acetyl aspartate, creatine + phosphocreatine, and choline in different parts of the brain in adulthood and senium. Magn Reson Imaging 1993;11:799-806

    CrossRefPubMedWeb of Science
29. 29.↵
    Lentner C, ed Geigy Scientific Tables. Basle: Ciba-Geigy; 1981
30. 30.↵
    Pfund Z, Chugani DC, Juhasz C, et al. Evidence for coupling between glucose metabolism and glutamate cycling using FDG PET and 1H magnetic resonance spectroscopy in patients with epilepsy. J Cereb Blood Flow Metab 2000;20:871-878

    PubMedWeb of Science
31. 31.↵
    Pirttila TR, Hakumaki JM, et al. 1H nuclear magnetic resonance spectroscopy study of cerebral glutamate in an ex vivo brain preparation of guinea pig. J Neurochem 1993;60:1274-1282

    CrossRefPubMedWeb of Science
32. 32.
    Kauppinen RA, Williams SR. Nondestructive detection of glutamate by 1H nuclear magnetic resonance spectroscopy in cortical brain slices from the guinea pig: evidence for changes in detectability during severe anoxic insults. J Neurochem 1991;57:1136-1144

    CrossRefPubMed
33. 33.↵
    Kauppinen RA, Williams SR, et al. Applications of magnetic resonance spectroscopy and diffusion-weighted imaging to the study of brain biochemistry and pathology. Trends Neurosci 1993;16:88-95

    CrossRefPubMedWeb of Science
34. 34.↵
    Burri R, Bigler P, Straehl P, Posse S, Colombo JP, Herschkowitz N. Brain development: 1H magnetic resonance spectroscopy of rat brain extracts compared with chromatographic methods. Neurochem Res 1990;15:1009-1016

    CrossRefPubMed
35. 35.↵
    Kauppinen RA, Pirttila TR, et al. Compartmentation of cerebral glutamate in situ as detected by 1H/13C n.m.r. Biochem J 1994;298:121-127
36. 36.↵
    Zorumski CF, Olney JW. Excitotoxic neuronal damage and neuropsychiatric disorders. Pharmacol Ther 1993;59:145-162

    CrossRefPubMedWeb of Science
37. 37.↵
    Clark JB. N-acetyl aspartate: a marker for neuronal loss or mitochondrial dysfunction. Dev Neurosci 1998;20:271-276

    CrossRefPubMedWeb of Science
38. 38.↵
    Ross B, Michaelis T. Clinical applications of magnetic resonance spectroscopy. Magn Reson Q 1994;10:191-247

    PubMedWeb of Science
39. 39.↵
    Young RSK, Petroff OAC, Chen B, Gore JC, Aquila WJ. Brain energy state and lactate metabolism during status epilepticus in the neonatal dog: in vivo 31P and 1H nuclear magnetic resonance study. Pediatr Res 1991;29:191-195
40. 40.↵
    Young RSK, Chen B, Petroff OAC, et al. The effect of diazepam on neonatal seizure: in vivo 31P and 1H NMR study. Pediatr Res 1989;25:27-31

    CrossRefPubMed
41. 41.↵
    Petroff OAC, Prichard JW, Behar KL, Alger JR, Shulman RG. In vivo phosphorus nuclear magnetic resonance spectroscopy in status epilepticus. Ann Neurol 1984;16:169-177

    CrossRefPubMedWeb of Science
42. 42.↵
    Prichard JW. Nuclear magnetic resonance spectroscopy of seizure states. Epilepsia 1994;35:S14-S20
43. 43.↵
    Young RSK, Osbakken MD, Briggs RW, Yagel SK, Rice DW, Goldberg S. 31P NMR study of cerebral metabolism during prolonged seizures in the neonatal dog. Ann Neurol 1985;18:14-20

    CrossRefPubMedWeb of Science
44. 44.↵
    Korn GA, Korn TM. Mathematical Handbook for Scientists and Engineers. New York: McGraw-Hill; 1968:1130
45. 45.↵
    Najm IM, Wang Y, Hong SC, Luders HO, Ng TC, Comair YG. Temporal changes in proton MRS metabolites after kainic acid-induced seizures in rat brain. Epilepsia 1997;38:87-94

    CrossRefPubMed
46. 46.↵
    Breiter SN, Arroyo S, Mathews VP, Lesser RP, Bryan RN, Barker PB. Proton MR spectroscopy in patients with seizure disorders. AJNR Am J Neuroradiol 1994;15:373-384

    Abstract/FREE Full Text
47. 47.↵
    Fox PT, Raichle ME. Focal physiological uncoupling of cerebral blood flow and oxidative metabolism during somatosensory stimulation in human subjects. Proc Natl Acad Sci USA 1986;83:1140-1144

    Abstract/FREE Full Text
48. 48.
    Fox PT, Raichle ME. Nonoxidative glucose consumption during focal physiologic neural activity. Science 1988;241:462-464

    Abstract/FREE Full Text
49. 49.
    Lear JL. Glycolysis: link between PET and proton MR spectroscopic studies of the brain. Radiology 1990;174:328-330

    PubMedWeb of Science
50. 50.
    Prichard J, Rothman D, et al. Lactate rise detected by 1H NMR in human visual cortex during physiologic stimulation. Proc Natl Acad Sci USA 1991;88:5829-5831

    Abstract/FREE Full Text
51. 51.
    Sappey-Marinier D, Calabrese G, et al. Effect of photic stimulation on human visual cortex lactate and phosphates using 1H and 31P magnetic resonance spectroscopy. J Cereb Blood Flow Metab 1992;12:584-592

    PubMedWeb of Science
52. 52.↵
    Magistretti PJ, Sorg O, Yu N, Martin JL, Pellerin L, et al. Neurotransmitters regulate energy metabolism in astrocytes: implications for the metabolic trafficking between neural cells. Dev Neurosci 1993;15:306-312

    CrossRefPubMedWeb of Science
53. McIlwain H. Electrical influences and speed of chemical change in the brain. Physiol Rev 1956;36:355-375

    FREE Full Text
54. 54.↵
    Pellerin L, Magistretti PJ. Glutamate uptake into astrocytes stimulates aerobic glycolysis: a mechanism coupling neuronal activity to glucose utilization. Proc Natl Acad Sci USA 1994;91:10625-10629

    Abstract/FREE Full Text
55. 55.↵
    Siesjo B, von Hanwehr R, Nergelius G, Nevander G, Ingvar M. Extra- and intracellular pH in the brain during seizures and in the recovery period following the arrest of seizure activity. J Cereb Blood Flow Metab 1985;5:47-57

    PubMedWeb of Science
56. 56.↵
    Magistretti P, Pellerin L. Cellular mechanisms of brain energy metabolism and their relevance to functional brain imaging. Philos Trans R Soc Lond B Biol Sci 1999;354:1155-1163

    Abstract/FREE Full Text
57. 57.
    Schurr A, Rigor B. Brain anaerobic lactate production: a suicide note or a survival kit? Dev Neurosci 1998;20:348-357

    CrossRefPubMedWeb of Science
58. 58.
    Gruetter R, Seaquist E, Kim S, Ugurbil K. Localized in vivo 13C-NMR of glutamate metabolism in the human brain: initial results at 4 tesla. Dev Neurosci 1998;20:380-388

    CrossRefPubMedWeb of Science
59. 59.
    Murata T, Waki A, Omata N, et al. Dynamic changes in glucose metabolism by lactate loading as revealed by a positron autoradiography technique using rat living brain slices. Neurosci Lett 1998;249:155-158

    CrossRefPubMed
60. 60.
    Hu Y, Wilson G. A temporary local energy pool coupled to neuronal activity: fluctuations of extracellular lactate levels in rat brain monitored with rapid-response enzyme-based sensor. J Neurochem 1997;69:1484-1490

    PubMedWeb of Science
61. 61.↵
    Castillo M. Imaging intractable epilepsy: how many tests are enough? AJNR Am J Neuroradiol 1999;20:534-535

    FREE Full Text
62. 62.↵
    Woods BT, Chiu TM. In vivo 1H spectroscopy of the human brain following electroconvulsive therapy. Ann Neurol 1990;28:745-749

    CrossRefPubMedWeb of Science
63. 63.↵
    Woods BT, Chiu TM. Induced and spontaneous seizures in man produce increases in regional brain lipid detected by in vivo proton magnetic resonance spectroscopy. Adv Exp Med Biol 1992;318:267-274

    PubMed
64. 64.↵
    Bazan NG Jr. Effects of ischemia and electroconvulsive shock on free fatty acid pool in the brain. Biochim Biophys Acta 1970;218:1-10

    CrossRefPubMedWeb of Science
65. 65.
    Bazan NG Jr. Changes in free fatty acids of brain by drug-induced convulsions, electroshock and anaesthesia. J Neurochem 1971;18:1379-1385

    CrossRefPubMedWeb of Science
66. 66.↵
    Sterns RH, Thomas DJ, Herndon RM. Brain dehydration and neurologic deterioration after rapid correction of hyponatremia. Kidney Int 1989;35:69-75

    CrossRefPubMedWeb of Science
67. 67.↵
    Torack RM, Alcala H, Gado M, Burton R. Correlative assay of computerized cranial tomography (CCT), water content and specific gravity in normal and pathological postmortem brain. J Neuropathol Exp Neurol 1976;35:385-392

    PubMed
68. 68.↵
    MacDonald HL, Bell BA, Smith MA, et al. Correlation of human NMR T1 values measured in vivo and brain water content. Br J Radiol 1986;59:355-357

    Abstract/FREE Full Text
69. 69.↵
    Bell BA, Smith MA, Kean DM, et al. Brain water measured by magnetic resonance imaging. Lancet 1987;1:66-69

    PubMedWeb of Science
70. 70.↵
    Zhong J, Petroff OAC, Prichard JW, Gore JC. Changes in water diffusion and relaxation properties of rat cerebrum during status epilepticus. Magn Reson Med 1993;30:241-246

    PubMedWeb of Science
71. 71.
    Zhong J, Petroff OAC, Prichard JW, Gore JC. Barbiturate-reversible reduction of water diffusion coefficient in flurothyl-induced status epilepticus in rats. Magn Reson Med 1995;33:253-256

    PubMedWeb of Science
72. 72.↵
    Mansfield P, Morris PG. NMR Imaging in Biomedicine. New York: Academic Press; 1982
73. 73.↵
    Inch WR, McCredie JA, et al. Water content and proton spin relaxation time for neoplastic and non-neoplastic tissues from mice and humans. J Natl Cancer Inst 1974;52:353-356
74. 74.
    Kiricuta IC Jr, Simplaceanu V. Tissue water content and nuclear magnetic resonance in normal and tumor tissues. Cancer Res 1975;35:1164-1167

    Abstract/FREE Full Text
75. 75.
    Saryan LA, Hollis DP. Nuclear magnetic resonance studies of cancer, IV: correlation of water content with tissue relaxation times. J Natl Cancer Inst 1974;52:599-602
76. 76.
    Fatouros PP, Marmarou A, et al. In vivo brain water determination by T1 measurements: effect of total water content, hydration fraction, and field strength. Magn Reson Med 1991;17:402-413

    PubMedWeb of Science
77. 77.
    Alger JR, Symko SC, Bizzi A, Posse S, DesPres DJ, Armstrong MR. Absolute quantitation of short TE brain 1H-MR spectra and spectroscopic imaging data. J Comput Assist Tomogr 1993;17:191-199

    PubMed
78. 78.
    Oppenheimer SM, Bryan RN, Conturo TE, Soher BJ, Preziosi TJ, Barker PB. Proton magnetic resonance spectroscopy and gadolinium-DTPA perfusion imaging of asymptomatic MRI white matter lesions. Magn Reson Med 1995;33:61-68

    PubMed
79. 79.↵
    Biziere K, Chambon JP. Modeles animaux d'epilepsie et crises experimentales. Rev Neurol 1987;143:329-340

    PubMed
80. 80.↵
    Katzung BG, ed Basic & Clinical Pharmacology. Stamford, CT: Appleton & Lange; 1998
81. 81.↵
    Dawson-Saunders , Basic & Clinical Biostatistics. 2nd ed. Norwalk, CT: Appleton & Lange; 1994:344
82. 82.↵
    Pfeuffer J, Tkac I, Gruetter R. Extracellular-intracellular distribution of glucose and lactate in the rat brain assessed noninvasively by diffusion-weighted 1H nuclear magnetic resonance spectroscopy in vivo. J Cereb Blood Flow Metab 2000;20:736-746

    PubMedWeb of Science
83. 83.↵
    Gilboe DD, Kintner DB, Anderson ME, Fitzpatrick JH. NMR-based identification of intra- and extracellular compartments of the pi peak. J Neurochem 1998;71:2542-2548

    PubMed