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Research ArticleSPINE

Carcinoid Tumor Development in an Intramedullary Spinal Cord Mature Teratoma

Xuemo Fan, Jennifer E. Turner, Thomas M. Turner, James P. Elrod, John A. Clough, Everette I. Howell and Mahlon D. Johnson
American Journal of Neuroradiology October 2001, 22 (9) 1778-1781;
Xuemo Fan
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Jennifer E. Turner
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Thomas M. Turner
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James P. Elrod
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John A. Clough
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Everette I. Howell
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Mahlon D. Johnson
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Figures

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    fig 1.

    Sagittal MR images of the lumbar spine reveal the heterogeneous appearance of the mass indicative of a variety of components.

    A, On T1-weighted image, most of the mass is hyperintense (arrowhead) with a hypointense mural nodule (arrow).

    B, On T2-weighted image, the mass shows mixed signal intensities (arrow). The cystic lesion within the spinal cord proximal to the mass is quite visible (arrowhead).

    C, After administration of gadopentetate dimeglumine, T1-weighted image shows the intense enhancement of the nodular component (arrow).

    D, Axial T1-weighted image shows the mass (arrow) within the spinal canal, with leftward displacement of the conus medullaris.

  • fig 2.
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    fig 2.

    Specimen for macroscopic examination shows well-encapsulated soft-tissue mass with a smooth, tan external surface. Cut surfaces show a cystic mass with a mural firm pink-tan nodule that attached to the cyst wall by a narrow stalk. The cut surfaces of the nodule are pink-tan without evidence of hemorrhage or necrosis. The rest of the internal surface is yellow-tan and focally covered with yellow, greasy material

  • fig 3.
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    fig 3.

    Photomicrographs of a mature cystic teratoma with an intramural carcinoid.

    A, Carcinoid component of teratoma shown juxtaposed to cystic wall of teratoma by a narrow stalk (hematoxylin and eosin stain).

    B, Mucin-secreting columnar epithelium within carcinoid component (hematoxylin and eosin stain).

    C, Carcinoid cells with intracytoplasmic argyrophil granules (Pascual stain).

    D and E, Immunohistochemistry shows strong diffuse cytoplasmic positive staining for synaptophysin (D) and weak membrane-like pattern for PSAP in carcinoid (E) (diaminobenzidine chromogen with hematoxylin counterstain).

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American Journal of Neuroradiology: 22 (9)
American Journal of Neuroradiology
Vol. 22, Issue 9
1 Oct 2001
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Cite this article
Xuemo Fan, Jennifer E. Turner, Thomas M. Turner, James P. Elrod, John A. Clough, Everette I. Howell, Mahlon D. Johnson
Carcinoid Tumor Development in an Intramedullary Spinal Cord Mature Teratoma
American Journal of Neuroradiology Oct 2001, 22 (9) 1778-1781;

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Carcinoid Tumor Development in an Intramedullary Spinal Cord Mature Teratoma
Xuemo Fan, Jennifer E. Turner, Thomas M. Turner, James P. Elrod, John A. Clough, Everette I. Howell, Mahlon D. Johnson
American Journal of Neuroradiology Oct 2001, 22 (9) 1778-1781;
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