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Research ArticleBRAIN

Time-Threshold Curve Determined by Single Photon Emission CT in Patients with Acute Middle Cerebral Artery Occlusion

Tsutomu Iseda, Shinichi Nakano, Takao Yano, Yukiko Suzuki and Shinichiro Wakisaka
American Journal of Neuroradiology April 2002, 23 (4) 572-576;
Tsutomu Iseda
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Shinichi Nakano
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Takao Yano
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Yukiko Suzuki
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Shinichiro Wakisaka
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    Fig 1.

    Graph shows relationship between outcome in tissue regions that were successfully reperfused and ischemic duration/severity. Plots of AI (%) of irreversible (•) and reversible (□) lesions versus ischemic duration are shown. A discriminant line of AI (%) = 21.53 time (h) − 19.15 (n = 35) within 3 hours of ischemic duration can be seen. There are six (17%) falsely discriminated ischemic lesions. A discriminant line of AI = 0.50 time − 48.27 (n = 92) after 3 hours’ ischemic duration can be seen. There are 10 (11%) falsely discriminated ischemic lesions.

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    Fig 2.

    Case 9.

    A, Final CT scan shows that an infarct occupied approximately half the right MCA territory. Posterior half of the MCA territory escaped cerebral infarction.

    B, SPECT scan shows severe hypoperfusion with an AI of 14.89 in the anterior half of the MCA territory, which experienced infarction, and mild hypoperfusion with an AI of 70.82 in the posterior half of the MCA territory, which escaped infarction.

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    TABLE

    Clinical and radiologic characteristics for 19 patients

    CaseAge (y)/SexOcclusion SiteTreatment Thrombolytic AgentsTime to Reperfusion (h)Initial SymptomsInfarct on CTOutcome
    158/FL M2t-PA 7.2 IA4.0Hemiparesis, aphasia3-cm frontal infarctE
    271/ML M2t-PA 7.2 IA3.0Hemiplegia, aphasiaE
    379/FR M1PTA3.3Hemiplegia2-cm basal ganglia infarctG
    481/MR M1PTA, t-PA 7.2 IA4.8Hemiparesis2-cm basal ganglia infarctG
    574/FR M2t-PA 7.2 IA2.5HemiplegiaE
    686ML M1PTA3.5Hemiplegia, aphasia4-cm basal ganglia infarctF
    758/FL M2t-PA 7.2 IA3.3Hemiplegia, aphasia4-cm temporoparietal infarctG
    878/MR M1PTA, t-PA 7.2 IA8.0Hemiparesis3-cm basal ganglia infarctG
    965/MR M1PTA2.5Hemiparesis60% of the MCA territoryF
    1076/ML M1t-PA 7.2 IA4.8Hemiparesis, aphasiaE
    1172/FL M1PTA, t-PA 7.2 IA5.5Hemiplegia, aphasia2-cm basal ganglia infarctE
    1274/FR M1PTA, t-PA 7.2 IA2.8Hemiparesis2-cm parietal infarctE
    1371/ML M1PTA, t-PA 7.2 IA2.8Hemiplegia, aphasiaE
    1467/MR M1PTA, t-PA 7.2 IA3.8Hemiparesis3-cm basal ganglia infarctG
    1580/MR M1PTA, t-PA 7.2 IA4.5Hemiplegia3-cm temporoparietal infarctG
    1668/MR M1PTA, t-PA 7.2 IA5.5Hemiparesis2-cm basal ganglia infarctE
    1760/FL M1PTA, t-PA 7.2 IA4.0Hemiplegia, aphasia3-cm basal ganglia infarctE
    1849/MR M1PTA, t-PA 7.2 IA6.9Hemiparesis2-cm temporoparietal infarctE
    1958/FL M2t-PA 7.2 IA3.3Hemiplegia, aphasia3-cm frontal infarctE
    • Note.—L indicates left; R, right; t-PA, tissue plasminogen activator (mg); IA, intraarterial infusion; PTA, percutaneous transluminal angioplasty; MCA, middle cerebral artery; E, excellent (complete recovery); G, good (partially recovered with self-care); F, fair (no neurologic change).

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American Journal of Neuroradiology: 23 (4)
American Journal of Neuroradiology
Vol. 23, Issue 4
1 Apr 2002
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Cite this article
Tsutomu Iseda, Shinichi Nakano, Takao Yano, Yukiko Suzuki, Shinichiro Wakisaka
Time-Threshold Curve Determined by Single Photon Emission CT in Patients with Acute Middle Cerebral Artery Occlusion
American Journal of Neuroradiology Apr 2002, 23 (4) 572-576;

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Time-Threshold Curve Determined by Single Photon Emission CT in Patients with Acute Middle Cerebral Artery Occlusion
Tsutomu Iseda, Shinichi Nakano, Takao Yano, Yukiko Suzuki, Shinichiro Wakisaka
American Journal of Neuroradiology Apr 2002, 23 (4) 572-576;
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