Skip to main content
Advertisement

Main menu

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home

User menu

  • Alerts
  • Log in

Search

  • Advanced search
American Journal of Neuroradiology
American Journal of Neuroradiology

American Journal of Neuroradiology

ASHNR American Society of Functional Neuroradiology ASHNR American Society of Pediatric Neuroradiology ASSR
  • Alerts
  • Log in

Advanced Search

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home
  • Follow AJNR on Twitter
  • Visit AJNR on Facebook
  • Follow AJNR on Instagram
  • Join AJNR on LinkedIn
  • RSS Feeds

AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticleBrain

Diffusion Tensor MR Imaging in Diffuse Axonal Injury

Konstantinos Arfanakis, Victor M. Haughton, John D. Carew, Baxter P. Rogers, Robert J. Dempsey and M. Elizabeth Meyerand
American Journal of Neuroradiology May 2002, 23 (5) 794-802;
Konstantinos Arfanakis
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Victor M. Haughton
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
John D. Carew
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Baxter P. Rogers
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Robert J. Dempsey
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
M. Elizabeth Meyerand
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • Responses
  • References
  • PDF
Loading

References

  1. ↵
    Kraus J, Nourjah P. The epidemiology of mild head injury. In: Levin H, Eisenberg H, Benton A, eds. Mild Head Injury. Oxford: Oxford University Press;1989 :8–22
  2. ↵
    Mittl RJ, Grossman RI, Hiehle JF, et al. Prevalence of MR evidence of diffuse axonal injury in patients with mild head injury and normal head CT findings. AJNR Am J Neuroradiol 1994;15:1583–1589
    Abstract/FREE Full Text
  3. ↵
    Capruso DX, Levin HS. Cognitive impairment following closed head injury. Neurol Clin 1992;10:879–893
    PubMedWeb of Science
  4. Evans RW. The postconcussion syndrome and the sequelae of mild head injury. Neurol Clin 1992;10:815–847
    PubMedWeb of Science
  5. ↵
    Levin HS, Mattis S, Ruff RM, et al. Neurobehavioral outcome following minor head injury: a three-center study. J Neurosurg 1987;66:234–243
    PubMedWeb of Science
  6. ↵
    Holbourn AHS. The mechanics of brain injuries. Br Med Bull 1945;3:147–149
    FREE Full Text
  7. ↵
    Adams JH. Head injury. In: Adams JH, Corsellis JAN, Duchen LW, eds. Greenfield’s Neuropathology. 4th ed. New York: John Wiley and Sons;1984 :85–124
  8. ↵
    Povlishock JT, Christman JT. The pathobiology of traumatically induced axonal injury animals and humans: a review of current thoughts. J Neurotrauma 1995;12:555–564
    PubMedWeb of Science
  9. ↵
    Christman CW, Grady MS, Walker SA, Holloway KL, Povlishock JT. Ultrastructural studies of diffuse axonal injury in humans. J Neurotrauma 1994;11:173–186
    CrossRefPubMedWeb of Science
  10. Grady MS, McLaughlin MR, Christman CW, Valadka AB, Fligner CL, Povlishock JT. The use of antibodies targeted against the neurofilament subunits for the detection of diffuse axonal injury in humans. J Neuropathol Exp Neurol 1993;52:143–152
    PubMedWeb of Science
  11. ↵
    Pettus EH, Christman CW, Giebel ML, Povlishock JT. Traumatically induced altered membrane permeability: its relationship to traumatically induced reactive axonal change. J Neurotrauma 1994;11:507–522
    PubMedWeb of Science
  12. ↵
    Gennarelli TA. The pathobiology of traumatic brain injury. Neuroscientist 1997;3:73–81
  13. ↵
    Gennarelli TA, Thibault LE, Tipperman R, et al. Axonal injury in the optic nerve: a model simulating diffuse axonal injury in the brain. J Neurosurg 1989;71:244–253
    PubMedWeb of Science
  14. Maxwell WL, Kansagra AM, Graham DI, Adams JH, Gennarelli TA. Freeze-fracture studies of reactive myelinated nerve fibers after diffuse axonal injury. Acta Neuropathol 1988;76:395–406
    CrossRefPubMed
  15. ↵
    Tomei G, Spagnoli D, Ducati A, et al. Morphology and neurophysiology of focal axonal injury experimentally induced in the guinea pig optic nerve. Acta Neuropathol 1990;80:506–513
    CrossRefPubMed
  16. ↵
    Ong L, Selladurai BM, Dhillon MK, Atan M, Lye MS. The prognostic value of the Glasgow Coma Scale, hypoxia and computerized tomography in outcome prediction of pediatric head injury. Pediatr Neurosurg 1996;24:285–291
    PubMedWeb of Science
  17. ↵
    Kelly AB, Zimmerman RD, Snow RB, Gandy SE, Heier LA, Deck MDF. Head trauma: comparison of MR and CT—experience in 100 patients. AJNR Am J Neuroradiol 1988;9:699–708
    Abstract/FREE Full Text
  18. Friedman SD, Brooks WM, Jung RE, Hart BL, Yeo RA. Proton MR spectroscopic findings correspond to neuropsychological function in traumatic brain injury. AJNR Am J Neuroradiol 1998;19:1879–1885
    Abstract
  19. Hofman PAM, Stapert SZ, van Kroonenburgh MJPG, Jolles J, de Krujik J, Wilmink JT. MR imaging, single-photon emission CT, and neurocognitive performance after mild traumatic brain injury. AJNR Am J Neuroradiol 2001;22:441–449
    Abstract/FREE Full Text
  20. Hofman PAM, Kemerink GJ, Jolles J, Wilmink JT. Quantitative analysis of magnetization transfer images of the brain: effect of closed head injury, age and sex on white matter. Magn Reson Med 1999;42:803–806
    CrossRefPubMedWeb of Science
  21. ↵
    Liu A, Maldijian J, Bagley L, Sinson G, Grossman R. Traumatic brain injury: diffusion weighted imaging findings. AJNR Am J Neuroradiol 1999;20:1634–1641
  22. ↵
    Adams JH, Graham DI, Murray LS, Scott G. Diffuse axonal injury due to nonmissile head injury in humans: an analysis of 45 cases. Ann Neurol 1982;12:557–563
    CrossRefPubMedWeb of Science
  23. ↵
    Basser PJ, Mattiello J, Le Bihan D. MR diffusion tensor spectroscopy and imaging. Biophys J 1994;66:259–267
    CrossRefPubMedWeb of Science
  24. ↵
    Basser PJ, Mattiello J, Le Bihan D. Estimation of the effective self-diffusion tensor from the NMR spin echo. J Magn Reson B 1994;103:247–254
    CrossRefPubMedWeb of Science
  25. ↵
    Pierpaoli C, Jezzard P, Basser PJ, Barnett A, Di Chiro G. Diffusion tensor MR imaging of the human brain. Radiology 1996;201:637–648
    PubMedWeb of Science
  26. ↵
    Virta A, Barnett A, Pierpaoli C. Visualizing and characterizing white matter fiber structure and architecture in the human pyramidal tract using diffusion tensor MRI. Magn Reson Imaging 1999;17:1121–1133
    CrossRefPubMedWeb of Science
  27. ↵
    Holmes AA, Scollan DF, Winslow RL. Direct histological validation of diffusion tensor MRI in formaldehyde-fixed myocardium. Magn Reson Med 2000;44:157–161
    CrossRefPubMedWeb of Science
  28. ↵
    Fenyes DA, Narayana PA. In vivo diffusion tensor imaging of rat spinal cord with echo planar imaging. Magn Reson Med 1999;42:300–306
    CrossRefPubMed
  29. ↵
    Lythgoe MF, Busza AL, Calamante F, et al. Effects of diffusion anisotropy on lesion delineation in a rat model of cerebral ischemia. Magn Reson Med 1997;38:662–668
    PubMed
  30. ↵
    van Gelderen P, de Vleeschouwer MHM, DesPres D, Pekar J, van Zijl PCM, Moonen CTW. Water diffusion and acute stroke. Magn Reson Med 1994;31:154–163
    PubMedWeb of Science
  31. ↵
    Werring DJ, Clark CA, Barker GJ, Thompson AJ, Miller DH. Diffusion tensor imaging of lesions and normal-appearing white matter in multiple sclerosis. Neurology 1999;52:1626–1632
    Abstract/FREE Full Text
  32. ↵
    Le Bihan D. Diffusion NMR imaging. Magn Reson Q 1991;7:1–30
    PubMed
  33. ↵
    Basser PJ. Inferring microstructural features and the physiological state of tissues from diffusion-weighted images. NMR in Biomedicine 1995;8:333–344
    CrossRefPubMedWeb of Science
  34. Basser PJ, Pierpaoli C. Microstructural and physiological features of tissues elucidated by quantitative-diffusion-tensor MRI. J Magn Reson B 1996;111:209–219
    CrossRefPubMedWeb of Science
  35. ↵
    Pierpaoli C, Basser PJ. Toward a quantitative assessment of diffusion anisotropy. Magn Reson Med 1996;36:893–906
    CrossRefPubMedWeb of Science
  36. ↵
    Haselgrove JC, Moore JR. Correction for distortion of echo-planar images used to calculate the apparent diffusion coefficient. Magn Reson Med 1996;36:960–964
    CrossRefPubMedWeb of Science
  37. ↵
    Woods RP, Grafton ST, Holmes CJ, Cherry SR, Mazziotta JC. Automated image registration, I: general methods and intrasubject, intramodality validation. J Comp Assist Tomogr 1998;22:141–154
  38. ↵
    Pajevic S, Pierpaoli C. Color schemes to represent the orientation of anisotropic tissues from diffusion tensor data: application to white matter fiber tract mapping in the human brain. Magn Reson Med 1999;42:526–540
    CrossRefPubMedWeb of Science
  39. ↵
    Adams JH. Head injury. In: Adams JH, Duchen LW, eds. Greenfield’s Neuropathology. 5th ed. London: Edward Arnold;1992 :106–152
  40. ↵
    Gentleman SM, Nash MJ, Sweeting CJ, Graham DI, Roberts GW. β-Amyloid precursor protein (β-APP) as a marker for axonal injury after head injury. Neurosci Lett 1993;160:139–144
    CrossRefPubMedWeb of Science
  41. ↵
    Le Bihan D, Mangin JF, Poupon C, et al. Diffusion tensor imaging: concepts and applications. J Magn Reson 2001;13:534–546
  42. ↵
    Rugg-Gunn FJ, Symms MR, Barker GJ, Greenwood R, Duncan JS. Diffusion imaging shows abnormalities after blunt head trauma when conventional magnetic resonance imaging is normal. J Neurol Neurosurg Psychiatry 2001;70:530–533
    Abstract/FREE Full Text
  43. ↵
    Gennarelli TA, Thibault LE, Adams JH, Graham DI, Thompson CJ, Marcincin RP. Diffuse axonal injury and traumatic coma in the primate. Ann Neurol 1982;12:564–574
    CrossRefPubMedWeb of Science
  44. ↵
    Pfefferbaum A, Sullivan EV, Hedehus M, Lim KO, Adalsteinsson E, Moseley M. Age-related decline in brain white matter anisotropy measured with spatially corrected echo-planar diffusion tensor imaging. Magn Reson Med 2000;44:259–268
    CrossRefPubMedWeb of Science
PreviousNext
Back to top

In this issue

American Journal of Neuroradiology: 23 (5)
American Journal of Neuroradiology
Vol. 23, Issue 5
1 May 2002
  • Table of Contents
  • Index by author
Advertisement
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on American Journal of Neuroradiology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Diffusion Tensor MR Imaging in Diffuse Axonal Injury
(Your Name) has sent you a message from American Journal of Neuroradiology
(Your Name) thought you would like to see the American Journal of Neuroradiology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Cite this article
Konstantinos Arfanakis, Victor M. Haughton, John D. Carew, Baxter P. Rogers, Robert J. Dempsey, M. Elizabeth Meyerand
Diffusion Tensor MR Imaging in Diffuse Axonal Injury
American Journal of Neuroradiology May 2002, 23 (5) 794-802;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
0 Responses
Respond to this article
Share
Bookmark this article
Diffusion Tensor MR Imaging in Diffuse Axonal Injury
Konstantinos Arfanakis, Victor M. Haughton, John D. Carew, Baxter P. Rogers, Robert J. Dempsey, M. Elizabeth Meyerand
American Journal of Neuroradiology May 2002, 23 (5) 794-802;
del.icio.us logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Methods
    • Results
    • Discussion
    • Conclusion
    • References
  • Figures & Data
  • Info & Metrics
  • Responses
  • References
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • Volumetric and Diffusion Tensor Imaging biomarkers indicating long lasting post-concussion abnormalities in a youth pig model of mild Traumatic Brain Injury
  • Neuroprotective Effects of Naltrexone in a Mouse Model of Post-Traumatic Epilepsy
  • Differences in white matter detected by ex vivo 9.4T MRI are associated with axonal changes in the R6/1 model of Huntingtons Disease
  • Repetitive mild traumatic brain injury impairs resting state fMRI connectivity and alters protein profile signaling networks
  • White matter abnormalities characterise the acute stage of sports-related mild Traumatic Brain Injury
  • Automated detection of axonal damage along white matter tracts in acute severe traumatic brain injury
  • Personalized Connectome-Based Modeling in Patients with Semi-Acute Phase TBI: Relationship to Acute Neuroimaging and 6 Month Follow-Up
  • Correlation between Cranial Nerve Microstructural Characteristics and Vestibular Schwannoma Tumor Volume
  • Acute and Chronic Effects of Multiple Concussions on Midline Brain Structures
  • Effects of unilateral cortical resection of the visual cortex on bilateral human white matter
  • In utero diffusion tensor imaging of the fetal brain: a reproducibility study
  • Defining an Analytic Framework to Evaluate Quantitative MRI Markers of Traumatic Axonal Injury: Preliminary Results in a Mouse Closed Head Injury Model
  • Biomarkers of Traumatic Brain Injury: Temporal Changes in Body Fluids
  • Concussion is confusing us all
  • Traumatic Brain Injury Imaging Research Roadmap
  • Imaging Evidence and Recommendations for Traumatic Brain Injury: Advanced Neuro- and Neurovascular Imaging Techniques
  • Guidelines for the Ethical Use of Neuroimages in Medical Testimony: Report of a Multidisciplinary Consensus Conference
  • Docosahexaenoic Acid Reduces ER Stress and Abnormal Protein Accumulation and Improves Neuronal Function Following Traumatic Brain Injury
  • A Decade of DTI in Traumatic Brain Injury: 10 Years and 100 Articles Later
  • A Forensic Neuropsychiatric Approach to Traumatic Brain Injury, Aggression, and Suicide
  • Cognitive Impairment in Mild Traumatic Brain Injury: A Longitudinal Diffusional Kurtosis and Perfusion Imaging Study
  • Diffusion Abnormalities in Pediatric Mild Traumatic Brain Injury
  • Diffusion tensor imaging studies of mild traumatic brain injury: a meta-analysis
  • Diffusion Tensor Imaging in Mild Traumatic Brain Injury Litigation
  • Longitudinal study of carbon monoxide intoxication by diffusion tensor imaging with neurospsychiatric correlation
  • A prospective diffusion tensor imaging study in mild traumatic brain injury
  • Significant Temporal Evolution of Diffusion Anisotropy for Evaluating Early Response to Radiosurgery in Patients with Vestibular Schwannoma: Findings from Functional Diffusion Maps
  • Diffusion Tensor Imaging of the Subcortical Auditory Tract in Subjects with Congenital Cochlear Nerve Deficiency
  • Evaluation of Delayed Neuronal and Axonal Damage Secondary to Moderate and Severe Traumatic Brain Injury Using Quantitative MR Imaging Techniques
  • MRI Identification of White Matter Reorganization Enhanced by Erythropoietin Treatment in a Rat Model of Focal Ischemia
  • Diffusion tractography of axonal degeneration following shear injury
  • VERBAL MEMORY DEFICIT FOLLOWING TRAUMATIC BRAIN INJURY: ASSESSMENT USING ADVANCED MRI METHODS
  • Diffusion tensor imaging of acute mild traumatic brain injury in adolescents
  • The Toronto traumatic brain injury study: Injury severity and quantified MRI
  • Neuroradiological characterization of normal adult ageing
  • Diffusion Tensor Imaging Reliably Detects Experimental Traumatic Axonal Injury and Indicates Approximate Time of Injury
  • Proton MR Spectroscopy and MRI-Volumetry in Mild Traumatic Brain Injury
  • Evidence for white matter disruption in traumatic brain injury without macroscopic lesions
  • Enhanced visualization and quantification of magnetic resonance diffusion tensor imaging using the p:q tensor decomposition
  • Crossref
  • Google Scholar

This article has not yet been cited by articles in journals that are participating in Crossref Cited-by Linking.

More in this TOC Section

  • Optimal MRI Sequence for Identifying Occlusion Location in Acute Stroke: Which Value of Time-Resolved Contrast-Enhanced MRA?
  • Evaluating the Effects of White Matter Multiple Sclerosis Lesions on the Volume Estimation of 6 Brain Tissue Segmentation Methods
  • Quiet PROPELLER MRI Techniques Match the Quality of Conventional PROPELLER Brain Imaging Techniques
Show more Brain

Similar Articles

Advertisement

Indexed Content

  • Current Issue
  • Accepted Manuscripts
  • Article Preview
  • Past Issues
  • Editorials
  • Editor's Choice
  • Fellows' Journal Club
  • Letters to the Editor
  • Video Articles

Cases

  • Case Collection
  • Archive - Case of the Week
  • Archive - Case of the Month
  • Archive - Classic Case

More from AJNR

  • Trainee Corner
  • Imaging Protocols
  • MRI Safety Corner
  • Book Reviews

Multimedia

  • AJNR Podcasts
  • AJNR Scantastics

Resources

  • Turnaround Time
  • Submit a Manuscript
  • Submit a Video Article
  • Submit an eLetter to the Editor/Response
  • Manuscript Submission Guidelines
  • Statistical Tips
  • Fast Publishing of Accepted Manuscripts
  • Graphical Abstract Preparation
  • Imaging Protocol Submission
  • Evidence-Based Medicine Level Guide
  • Publishing Checklists
  • Author Policies
  • Become a Reviewer/Academy of Reviewers
  • News and Updates

About Us

  • About AJNR
  • Editorial Board
  • Editorial Board Alumni
  • Alerts
  • Permissions
  • Not an AJNR Subscriber? Join Now
  • Advertise with Us
  • Librarian Resources
  • Feedback
  • Terms and Conditions
  • AJNR Editorial Board Alumni

American Society of Neuroradiology

  • Not an ASNR Member? Join Now

© 2025 by the American Society of Neuroradiology All rights, including for text and data mining, AI training, and similar technologies, are reserved.
Print ISSN: 0195-6108 Online ISSN: 1936-959X

Powered by HighWire