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Research ArticleBrain

MR Imaging of Leptomeningeal Metastases: Comparison of Three Sequences

Sanjay K. Singh, Norman E. Leeds and Lawrence E. Ginsberg
American Journal of Neuroradiology May 2002, 23 (5) 817-821;
Sanjay K. Singh
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Norman E. Leeds
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Lawrence E. Ginsberg
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    Fig 1.

    Axial view MR images of a 41-year-old male patient with leptomeningeal metastases from laryngeal squamous cell carcinoma.

    A, Unenhanced FLAIR image (10,000/147; inversion time, 2200 ms) shows diffuse abnormal signal intensity in the subarachnoid space (arrowhead).

    B, Contrast-enhanced FLAIR image (10,000/147; inversion time, 2200 ms) shows diffuse abnormal signal intensity in the subarachnoid space (arrowheads).

    C, Contrast-enhanced T1-weighted MR image (600/8) is falsely negative. Parenchymal metastasis is also identified (arrow).

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    Fig 2.

    Axial view MR images of a 59-year-old male patient with leptomeningeal metastases from ependymoma.

    A, Unenhanced FLAIR image (10,000/147; inversion time, 2200 ms) appears unremarkable.

    B, Contrast-enhanced FLAIR image (10,000/147; inversion time, 2200 ms) appears unremarkable.

    C, Contrast-enhanced T1-weighted MR image (600/8) shows enhancement along the surface of the midbrain (arrowheads). Thickened, enhancing dura is also identified on the contrast-enhanced images.

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    Fig 3.

    Axial view MR images of a 26-year-old male patient with leptomeningeal metastases from leukemia.

    A, Unenhanced FLAIR image (10,000/147; inversion time, 2200 ms) is negative.

    B, Contrast-enhanced FLAIR image (10,000/147; inversion time, 2200 ms) is negative.

    C, Contrast-enhanced T1-weighted MR image (600/8) shows enhancement along the superior surface of the cerebellum (arrows). Artifact is noted in the right temporal and occipital lobes.

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    TABLE 1:

    Results of MR readings for leptomeningeal metastases in positive CSF cases

    Imaging Technique
    Unenhanced FLAIRContrast-enhanced T1-weighted MRContrast-enhanced FLAIR
    Positive2107
    Negative15710
    Sensitivity12% (2/17)59% (10/17)41% (7/17)
    • Note.—FLAIR indicates fluid-attenuated inversion recovery.

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    TABLE 2:

    Results of MR readings for negative leptomeningeal metastases cases

    Imaging Technique
    Unenhanced FLAIRContrast-enhanced T1-weighted MRContrast-enhanced FLAIR
    Negative535350
    Positive447
    Specificity93% (53/57)93% (53/57)88% (50/57)
    • Note.—FLAIR indicates fluid-attenuated inversion recovery.

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American Journal of Neuroradiology: 23 (5)
American Journal of Neuroradiology
Vol. 23, Issue 5
1 May 2002
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Cite this article
Sanjay K. Singh, Norman E. Leeds, Lawrence E. Ginsberg
MR Imaging of Leptomeningeal Metastases: Comparison of Three Sequences
American Journal of Neuroradiology May 2002, 23 (5) 817-821;

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MR Imaging of Leptomeningeal Metastases: Comparison of Three Sequences
Sanjay K. Singh, Norman E. Leeds, Lawrence E. Ginsberg
American Journal of Neuroradiology May 2002, 23 (5) 817-821;
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