Skip to main content
Advertisement

Main menu

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • AJNR Case Collection
    • Case of the Week Archive
    • Classic Case Archive
    • Case of the Month Archive
  • Special Collections
    • Spinal CSF Leak Articles (Jan 2020-June 2024)
    • 2024 AJNR Journal Awards
    • Most Impactful AJNR Articles
  • Multimedia
    • AJNR Podcast
    • AJNR Scantastics
    • Video Articles
  • For Authors
    • Submit a Manuscript
    • Author Policies
    • Fast publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Manuscript Submission Guidelines
    • Imaging Protocol Submission
    • Submit a Case for the Case Collection
  • About Us
    • About AJNR
    • Editorial Board
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home
  • Other Publications
    • ajnr

User menu

  • Alerts
  • Log in

Search

  • Advanced search
American Journal of Neuroradiology
American Journal of Neuroradiology

American Journal of Neuroradiology

ASHNR American Society of Functional Neuroradiology ASHNR American Society of Pediatric Neuroradiology ASSR
  • Alerts
  • Log in

Advanced Search

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • AJNR Case Collection
    • Case of the Week Archive
    • Classic Case Archive
    • Case of the Month Archive
  • Special Collections
    • Spinal CSF Leak Articles (Jan 2020-June 2024)
    • 2024 AJNR Journal Awards
    • Most Impactful AJNR Articles
  • Multimedia
    • AJNR Podcast
    • AJNR Scantastics
    • Video Articles
  • For Authors
    • Submit a Manuscript
    • Author Policies
    • Fast publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Manuscript Submission Guidelines
    • Imaging Protocol Submission
    • Submit a Case for the Case Collection
  • About Us
    • About AJNR
    • Editorial Board
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home
  • Follow AJNR on Twitter
  • Visit AJNR on Facebook
  • Follow AJNR on Instagram
  • Join AJNR on LinkedIn
  • RSS Feeds

Welcome to the new AJNR, Updated Hall of Fame, and more. Read the full announcements.


AJNR is seeking candidates for the position of Associate Section Editor, AJNR Case Collection. Read the full announcement.

 

Research ArticlePEDIATRICS

Proton MR Spectroscopy in the Diagnostic Evaluation of Suspected Mitochondrial Disease

Doris D. M. Lin, Thomas O. Crawford and Peter B. Barker
American Journal of Neuroradiology January 2003, 24 (1) 33-41;
Doris D. M. Lin
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Thomas O. Crawford
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Peter B. Barker
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • Responses
  • References
  • PDF
Loading

References

  1. ↵
    DiMauro S, Moraes CT. Mitochondrial encephalomyopathies. Arch Neurol 1993;50:1197–1208
    CrossRefPubMedWeb of Science
  2. Hanna MG, Nelson IP. Genetics and molecular pathogenesis of mitochondrial respiratory chain diseases. Cell Mol Life Sci 1999;55:691–706
    CrossRefPubMedWeb of Science
  3. ↵
    Simon DK, Johns DR. Mitochondrial disorders: clinical and genetic features. Annu Rev Med 1999;50:111–127
    CrossRefPubMedWeb of Science
  4. ↵
    Nissenkorn A, Zeharia A, Lev D, et al. Multiple presentation of mitochondrial disorders. Arch Dis Child 1999;81:209–214
    Abstract/FREE Full Text
  5. ↵
    Munoz A, Mateos F, Simon R, Garcia Silva MT, Cabello S, Arenas J. Mitochondrial diseases in children: neuroradiological and clinical features in 17 patients. Neuroradiology 1999;41:920–928
    CrossRefPubMedWeb of Science
  6. ↵
    Nissenkorn A, Zeharia A, Lev D, et al. Neurologic presentations of mitochondrial disorders. J Child Neurol 2000;15:44–48
    Abstract/FREE Full Text
  7. ↵
    Johns DR. Seminars in medicine of the Beth Israel Hospital, Boston: mitochondrial DNA and disease. N Engl J Med 1995;333:638–644
    CrossRefPubMedWeb of Science
  8. ↵
    Barkovich AJ, Good WV, Koch TK, Berg BO. Mitochondrial disorders: analysis of their clinical and imaging characteristics. AJNR Am J Neuroradiol 1993;14:1119–1137
    Abstract/FREE Full Text
  9. van der Knaap MS, Jakobs C, Valk J. Magnetic resonance imaging in lactic acidosis. J Inherit Metab Dis 1996;19:535–547
    CrossRefPubMedWeb of Science
  10. ↵
    Valanne L, Ketonen L, Majander A, Suomalainen A, Pihko H. Neuroradiologic findings in children with mitochondrial disorders. AJNR Am J Neuroradiol 1998;19:369–377
    Abstract
  11. ↵
    Argov Z. Functional evaluation techniques in mitochondrial disorders. Eur Neurol 1998;39:65–71
    CrossRefPubMedWeb of Science
  12. ↵
    Castillo M, Kwock L, Green C. MELAS syndrome: imaging and proton MR spectroscopic findings. AJNR Am J Neuroradiol 1995;16:233–239
    Abstract/FREE Full Text
  13. Pavlakis SG, Kingsley PB, Kaplan GP, Stacpoole PW, O’Shea M, Lustbader D. Magnetic resonance spectroscopy: use in monitoring MELAS treatment. Arch Neurol 1998;55:849–852
    CrossRefPubMedWeb of Science
  14. ↵
    Wilichowski E, Pouwels PJ, Frahm J, Hanefeld F. Quantitative proton magnetic resonance spectroscopy of cerebral metabolic disturbances in patients with MELAS. Neuropediatrics 1999;30:256–263
    PubMedWeb of Science
  15. ↵
    Matthews PM, Andermann F, Silver K, Karpati G, Arnold DL. Proton MR spectroscopic characterization of differences in regional brain metabolic abnormalities in mitochondrial encephalomyopathies. Neurology 1993;43:2484–2490
    Abstract/FREE Full Text
  16. ↵
    Barker PB, Soher BJ, Blackband SJ, Chatham JC, Mathews VP, Bryan RN. Quantitation of proton NMR spectra of the human brain using tissue water as an internal concentration reference. NMR Biomed 1993;6:89–94
    CrossRefPubMedWeb of Science
  17. ↵
    Duyn JH, Gillen J, Sobering G, van Zijl PC, Moonen CT. Multisection proton MR spectroscopic imaging of the brain. Radiology 1993;188:277–282
    PubMedWeb of Science
  18. ↵
    Evans OB, Parker CC, Haas RH, Naidu S, Moser HW, Block H-GO. Inborn errors of metabolism of the nervous system. In: Bradley WG, Daroff RB, Fenichel GM, Marsden CD, eds. Neurology in Clinical Practice: The Neurological Disorders. 3rd ed. Woburn: Butterworth-Heinemann;2000 :1595–1664
  19. ↵
    Servidei S. Mitochondrial encephalomyopathies: gene mutation. Neuromuscul Disord 2002;12:524–529
    CrossRefPubMed
  20. ↵
    Horska A, Kaufmann WE, Brant LJ, Naidu S, Harris JC, Barker PB. In vivo quantitative proton MRSI study of brain development from childhood to adolescence. J Magn Reson Imaging 2002;15:137–143
    CrossRefPubMedWeb of Science
  21. ↵
    Bowen J, Richards T, Maravilla K. MR imaging and proton MR spectroscopy in A-to-G substitution at nucleotide position 3243 of leucine transfer RNA. AJNR Am J Neuroradiol 1998;19:231–234
    Abstract
  22. ↵
    Dubeau F, De Stefano N, Zifkin BG, Arnold DL, Shoubridge EA. Oxidative phosphorylation defect in the brains of carriers of the tRNAleu(UUR) A3243G mutation in a MELAS pedigree. Ann Neurol 2000;47:179–185
    CrossRefPubMedWeb of Science
  23. ↵
    Cross JH, Gadian DG, Connelly A, Leonard JV. Proton magnetic resonance spectroscopy studies in lactic acidosis and mitochondrial disorders. J Inherit Metab Dis 1993;16:800–811
    CrossRefPubMed
  24. ↵
    De Stefano N, Matthews PM, Arnold DL. Reversible decreases in N-acetylaspartate after acute brain injury. Magn Reson Med 1995;34:721–727
    PubMedWeb of Science
  25. ↵
    Shungu DC, Sano M, Millar WS, et al. Metabolic, structural, and neuropsychological deficits in mitochondrial encephalopathies assessed by 1H MRSI, MRI, and neuropsychological testing. Presented at the International Society for Magnetic Resonance in Medicine Conference, Philadelphia, May 22–28,1999
  26. ↵
    Inao S, Marmarou A, Clarke GD, Andersen BJ, Fatouros PP, Young HF. Production and clearance of lactate from brain tissue, cerebrospinal fluid, and serum following experimental brain injury. J Neurosurg 1988;69:736–744
    PubMedWeb of Science
Back to top

In this issue

American Journal of Neuroradiology: 24 (1)
American Journal of Neuroradiology
Vol. 24, Issue 1
1 Jan 2003
  • Table of Contents
  • Index by author
Advertisement
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on American Journal of Neuroradiology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Proton MR Spectroscopy in the Diagnostic Evaluation of Suspected Mitochondrial Disease
(Your Name) has sent you a message from American Journal of Neuroradiology
(Your Name) thought you would like to see the American Journal of Neuroradiology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Cite this article
Doris D. M. Lin, Thomas O. Crawford, Peter B. Barker
Proton MR Spectroscopy in the Diagnostic Evaluation of Suspected Mitochondrial Disease
American Journal of Neuroradiology Jan 2003, 24 (1) 33-41;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
0 Responses
Respond to this article
Share
Bookmark this article
Proton MR Spectroscopy in the Diagnostic Evaluation of Suspected Mitochondrial Disease
Doris D. M. Lin, Thomas O. Crawford, Peter B. Barker
American Journal of Neuroradiology Jan 2003, 24 (1) 33-41;
del.icio.us logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Methods
    • Results
    • Discussion
    • Conclusion
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • Responses
  • References
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • Large-scale animal model study uncovers altered brain pH and lactate levels as a transdiagnostic endophenotype of neuropsychiatric disorders involving cognitive impairment
  • Alterations of Brain Metabolites in Adults With HIV: A Systematic Meta-analysis of Magnetic Resonance Spectroscopy Studies
  • Biotin-Responsive Basal Ganglia Disease: Neuroimaging Features before and after Treatment
  • Brain imaging in mitochondrial respiratory chain deficiency: combination of brain MRI features as a useful tool for genotype/phenotype correlations
  • Cerebral metabolic abnormalities in A3243G mitochondrial DNA mutation carriers
  • A guide to diagnosis and treatment of Leigh syndrome
  • Crossref
  • Google Scholar

This article has not yet been cited by articles in journals that are participating in Crossref Cited-by Linking.

More in this TOC Section

  • Comparison of Image Quality and Radiation Dose in Pediatric Temporal Bone CT Using Photon-Counting Detector CT and Energy-Integrating Detector CT
  • SyMRI & MR Fingerprinting in Brainstem Myelination
  • Pons&Vermis Localization on Fetal MRI Using U-Net
Show more Pediatrics

Similar Articles

Advertisement

Indexed Content

  • Current Issue
  • Accepted Manuscripts
  • Article Preview
  • Past Issues
  • Editorials
  • Editors Choice
  • Fellow Journal Club
  • Letters to the Editor

Cases

  • Case Collection
  • Archive - Case of the Week
  • Archive - Case of the Month
  • Archive - Classic Case

Special Collections

  • Special Collections

Resources

  • News and Updates
  • Turn around Times
  • Submit a Manuscript
  • Author Policies
  • Manuscript Submission Guidelines
  • Evidence-Based Medicine Level Guide
  • Publishing Checklists
  • Graphical Abstract Preparation
  • Imaging Protocol Submission
  • Submit a Case
  • Become a Reviewer/Academy of Reviewers
  • Get Peer Review Credit from Publons

Multimedia

  • AJNR Podcast
  • AJNR SCANtastic
  • Video Articles

About Us

  • About AJNR
  • Editorial Board
  • Not an AJNR Subscriber? Join Now
  • Alerts
  • Feedback
  • Advertise with us
  • Librarian Resources
  • Permissions
  • Terms and Conditions

American Society of Neuroradiology

  • Not an ASNR Member? Join Now

© 2025 by the American Society of Neuroradiology All rights, including for text and data mining, AI training, and similar technologies, are reserved.
Print ISSN: 0195-6108 Online ISSN: 1936-959X

Powered by HighWire