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Research ArticleINTERVENTIONAL

Technical Feasibility of Embolizing Aneurysms with Glue (n-butyl 2-cyanoacrylate): Experimental Study in Rabbits

Dae Chul Suh, Kil Soo Kim, Soo Mee Lim, Hai Bin Shi, Choong Gon Choi, Ho Kyu Lee and Dong Man Seo
American Journal of Neuroradiology September 2003, 24 (8) 1532-1539;
Dae Chul Suh
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Kil Soo Kim
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Soo Mee Lim
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Hai Bin Shi
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Choong Gon Choi
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Ho Kyu Lee
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Dong Man Seo
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  • Fig 1.
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    Fig 1.

    Aneurysm 1. Complete glue embolization of aneurysm without a coil framework.

    A, After obtaining this preembolization angiogram, 50% glue was injected for 2 minutes and 28 seconds under subtracted, real-time road-map fluoroscopy.

    B and C, Frozen images of early (B) and late (C) phases show slow enlargement of the cast without fragmentation.

    D and E, Angiograms obtained immediately after embolization (D) and at 2-month follow-up (E) show no residual lumen in the aneurysm and a patent carotid artery.

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    Fig 2.

    Aneurysm 4. Partially embolized aneurysm without a coil framework.

    A, After obtaining this preembolization angiogram, 40% glue was injected for 1 minute and 26 seconds under subtracted, real-time road-map fluoroscopy.

    B–D, Frozen images of the early (B), middle (C), and late (D) phases show leakage of the cast along the wall.

    E and F, Angiograms obtained immediately after embolization (E) and at 2-month follow-up (F) show persistent occlusion of the carotid artery.

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    Fig 3.

    Aneurysm 16. Complete embolization with a coil framework.

    A and B, After obtaining the preembolization angiogram (A), an 8 x 20-cm GDC was introduced into the aneurysm to make a coil framework (B) and 28% glue was injected for 2 minutes and 3 seconds under subtracted, real-time road-map fluoroscopy.

    C and D, Frozen images of the early (C) and late (D) phases.

    E and F, Angiorams obtained immediately after embolization (E) and at 2-month follow-up (F) reveal persistent obliteration of the aneurysm.

  • Fig 4.
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    Fig 4.

    Aneurysm 9. Partially embolized aneurysm after making a coil framework.

    A–C, After obtaining a preembolization angiogram (A), an 8 × 20-cm GDC was introduced into the aneurysm to make a coil framework (B) and 50% glue was injected for 1 minute 35 seconds under subtracted, real-time road-map fluoroscopy (C). Glue could not be further injected probably because of the premature cast within the microcatheter.

    D and E, Angiogram obtained immediately after embolization (D) shows a residual lumen within the aneurysm that appears smaller on the 2-month follow-up angiogram (E).

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    Fig 5.

    Aneurysm 13. Glue spillage during injection after making a coil framework.

    A–C, After obtaining a preembolization angiogram (A), a 5 × 15-cm GDC was introduced into the aneurysm to make a coil framework (B), and 33% glue was injected for 33 seconds under subtracted, real-time road-map fluoroscopy (C). Note the acute angle of the aneurysmal neck to the parent carotid artery.

    D and E, Angiogram obtained immediately after embolization (D) shows a filling defect caused by spilled glue, which has been absorbed on the 2-month follow-up angiogram (E).

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    TABLE 1:

    Summary of glue embolization in rabbit aneurysms

    Aneurysm No.GDCGlue Concentration (%)*Amount of Glue Injected (mL)Duration of Injection (min:s)Results2-month Follow-upComments
    1—500.62:28CompleteComplete
    2—500.52:30IncompleteDecreased residual sac
    3—400.52:13IncompleteND
    4—400.61:26Occlusion of parent arteryNo changeLeakage of glue during retrieval of microcatheter.
    5—330.53:35CompleteND
    6—330.53:9Occlusion of parent arteryNDLeakage of glue during retrieval of microcatheter.
    7—280.42:15IncompleteComplete
    8—280.82:45CompleteND
    98 × 20500.21:35IncompleteDecreased residual sac
    106 × 10500.445 secondsCompleteND
    116 × 15400.438 secondsCompleteComplete
    126 × 20400.41:25CompleteComplete
    135 × 15330.533 secondsCompleteCompleteSpillage of glue.
    145 × 15330.51:55IncompleteND
    156 × 20280.31:57CompleteComplete
    168 × 20280.62:3CompleteComplete
    • Note.—GDC indicates Guglielmi detachable coil; complete or incomplete, complete or incomplete obliteration of aneurysmal lumen on arteriogram; ND, not done.

    • * Concentration of glue in the mixture to iodized oil.

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American Journal of Neuroradiology: 24 (8)
American Journal of Neuroradiology
Vol. 24, Issue 8
1 Sep 2003
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Cite this article
Dae Chul Suh, Kil Soo Kim, Soo Mee Lim, Hai Bin Shi, Choong Gon Choi, Ho Kyu Lee, Dong Man Seo
Technical Feasibility of Embolizing Aneurysms with Glue (n-butyl 2-cyanoacrylate): Experimental Study in Rabbits
American Journal of Neuroradiology Sep 2003, 24 (8) 1532-1539;

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Technical Feasibility of Embolizing Aneurysms with Glue (n-butyl 2-cyanoacrylate): Experimental Study in Rabbits
Dae Chul Suh, Kil Soo Kim, Soo Mee Lim, Hai Bin Shi, Choong Gon Choi, Ho Kyu Lee, Dong Man Seo
American Journal of Neuroradiology Sep 2003, 24 (8) 1532-1539;
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