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Research ArticleBRAIN

Differential Aging of the Human Striatum: Longitudinal Evidence

Naftali Raz, Karen M. Rodrigue, Kristen M. Kennedy, Denise Head, Faith Gunning-Dixon and James D. Acker
American Journal of Neuroradiology October 2003, 24 (9) 1849-1856;
Naftali Raz
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Karen M. Rodrigue
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Kristen M. Kennedy
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Denise Head
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Faith Gunning-Dixon
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James D. Acker
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    Fig 1.

    An example of demarcation and tracing of three striatal regions of interest (caudate, putamen and globus pallidus) on a series of coronal images.

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    Fig 2.

    Scatter plots for two volumetric measures of three striatal regions of interest taken on 53 subjects 5 years apart. The lines indicate linear regression of adjusted volumes on age at time 1 (solid line) and time 2 (broken line). Observations at time 1 are represented by solid circles, and observations at time 2 by empty circles. Regional volumes are adjusted for the intracranial volume.

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    TABLE

    Cross-Sectional Age-Related Differences in Striatal Volumes Measured Five Years Apart

    NucleusRaw VolumeRegression of ICV-Adjusted Volume on Ager12
    Time 1Time 2Time 1Time 2
    MeanSDCVMeanSDCVSlopeSErageSlopeSErage
    Caudate9.421.140.129.001.090.12−.031.010−.41−.034.009−.47.95
    Putamen10.410.980.0910.011.020.10−.030.008−.46−.033.008−.49.89
    Globus Pallidus2.160.270.122.100.270.13.004.002.22.004.002.21.93
    • Note.—CV (coefficient of variation) is a ratio of standard deviation (SD) to the mean. The regression slopes are unstandardized regression coefficients measured in cc/year. SE is standard error of slope. All coefficients for the caudate nucleus and putamen are significantly different from zero, whereas those for the globus pallidus are not. The differences in slopes between the neostriatum (caudate and putamen) and paleostriatum are statistically significant (p < .05). Correlations are Pearson product moment coefficients. All correlations r > .23 are significantly different from zero.

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American Journal of Neuroradiology: 24 (9)
American Journal of Neuroradiology
Vol. 24, Issue 9
1 Oct 2003
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Cite this article
Naftali Raz, Karen M. Rodrigue, Kristen M. Kennedy, Denise Head, Faith Gunning-Dixon, James D. Acker
Differential Aging of the Human Striatum: Longitudinal Evidence
American Journal of Neuroradiology Oct 2003, 24 (9) 1849-1856;

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Differential Aging of the Human Striatum: Longitudinal Evidence
Naftali Raz, Karen M. Rodrigue, Kristen M. Kennedy, Denise Head, Faith Gunning-Dixon, James D. Acker
American Journal of Neuroradiology Oct 2003, 24 (9) 1849-1856;
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