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Research ArticleBrain

Diffusion Tensor Imaging of the Hippocampal Formation in Temporal Lobe Epilepsy

Bassam A. Assaf, Feroze B. Mohamed, Karine J. Abou-Khaled, J. Michael Williams, May S. Yazeji, John Haselgrove and Scott H. Faro
American Journal of Neuroradiology October 2003, 24 (9) 1857-1862;
Bassam A. Assaf
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Feroze B. Mohamed
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Karine J. Abou-Khaled
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J. Michael Williams
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May S. Yazeji
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John Haselgrove
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Scott H. Faro
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    Fig 1.

    Images in a patient with left-sided TLE.

    A, Coronal T2-weighted MR image. Note the abnormal anterior hippocampus with mild deformation on the left side compared with the right side.

    B, DTI at the same coronal level as in A. Note the marking of the ROI in the left and right HFs. The images in the upper right corner correspond to the diffusion (B0, top), trace D (middle), and FA (bottom) images.

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    TABLE 1:

    Summary of the patient population evaluated with DTI

    Patient/Sex/Age, yTLEHR MRITrace D, 10−3 mm2/sTrace DFA
    LRLateralizationL-RL-R LateralizationLRL-R
    1/F/40RR0.941.10R−0.16R0.0250.0150.010
    2/F/27RR0.820.93R−0.11R0.0170.0170
    3/M/31LL0.780.77N0.01N0.0140.021−0.007
    4/F/42LL0.890.76N0.13L0.0120.019−0.007
    5/F/38LN0.880.86N0.02N0.0120.019−0.007
    6/F/59RN0.830.82N0.01N0.0150.0140.001
    7/F/43LL0.970.83L0.14L0.0100.020−0.010
    8/M/49RR0.720.86N−0.14R0.0130.017−0.004
    9/F/42LL1.200.84L0.36L0.0110.021−0.010
    10/M/39LN0.850.74N0.11L0.0120.013−0.001
    11/M/50LL0.880.80N0.08N0.0130.0130
    12/F/37LN0.960.84L0.12L0.0110.0080.003
    • Note.—HR MRI indicates high-resolution MR imaging; N, normal.

    • View popup
    TABLE 2:

    Summary of the control-subject population evaluated with DTI

    Control Subject/Sex/Age, yTrace D, 10−3 mm2/sFA
    LRLR
    1/F/270.870.880.0100.009
    2/M/270.880.820.0150.009
    3/M/260.830.810.0130.012
    4/F/300.860.820.0130.016
    5/M/290.800.830.0160.019
    6/M/400.870.860.0150.014
    7/F/280.840.800.0200.016
    8/M/240.880.890.0140.016
    9/F/240.760.810.0120.016
    10/F/470.840.820.0130.016
    11/M/330.800.790.0140.017
    12/M/250.880.780.0160.020
    13/M/490.870.830.0130.016
    14/M/290.830.880.0210.017
    • View popup
    TABLE 3:

    Summary of statistical measurements of diffusivity and FA in the patient group

    MeasurementTrace DFA
    IpsilateralContralateralIpsilateralContralateral
    No. of cases12121212
    Minimum0.780.720.0100.008
    Maximum1.200.940.0170.025
    Mean0.930.810.0130.017
    Variance0.420.360.0050.022
    SD0.120.060.0020.005
    • View popup
    TABLE 4:

    Summary of statistical measurements of diffusivity and FA in the healthy control group

    MeasurementTrace DFA
    LRL-RLRL-R
    No. of cases141414141414
    Minimum0.760.78−0.050.0100.009−0.004
    Maximum0.880.890.100.0210.0200.006
    Mean0.840.830.010.0150.015−0.001
    SD0.040.030.040.0030.0030.003
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American Journal of Neuroradiology: 24 (9)
American Journal of Neuroradiology
Vol. 24, Issue 9
1 Oct 2003
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Cite this article
Bassam A. Assaf, Feroze B. Mohamed, Karine J. Abou-Khaled, J. Michael Williams, May S. Yazeji, John Haselgrove, Scott H. Faro
Diffusion Tensor Imaging of the Hippocampal Formation in Temporal Lobe Epilepsy
American Journal of Neuroradiology Oct 2003, 24 (9) 1857-1862;

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Diffusion Tensor Imaging of the Hippocampal Formation in Temporal Lobe Epilepsy
Bassam A. Assaf, Feroze B. Mohamed, Karine J. Abou-Khaled, J. Michael Williams, May S. Yazeji, John Haselgrove, Scott H. Faro
American Journal of Neuroradiology Oct 2003, 24 (9) 1857-1862;
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