Article Figures & Data
Figures
- Fig 1.
Mean percentage of correct responses and reaction times for T and P tasks for the control, far, and close groups. Asterisk indicates close < control participants (P < .05).
- Fig 2.
Mean volumes of the left and right heads of the caudate for the control, far, and close groups. Asterisk indicates close < control participants (P < .05).
- Fig 3.
Activation foci (P < .01) derived from the T-minus-C comparison for the control, far, and close groups. Top row, Axial sections are 6 mm superior to the anterior commissure–posterior commissure line. Bottom row, Sections represent the midsagittal plane.
- Fig 4.
Volume of activation in the thalamus, caudate/putamen, and pre-SMA/cingulate derived from the time-minus-control subtraction for the control, far, and close groups.
Tables
Subject demographics, CAG repeat size, and test scores
Measure Participants Far Close Control Age (years)* 33.0 (5.0) 41.1 (5.9) 38.0 (6.1) Education (years) 14.6 (2.4) 14.1 (1.7) 14.9 (1.9) Sex (M/F) (2/5) (4/3) (2/5) CAG repeat size† 41.3 (2.1) 44.2 (2.5) NA Estimated years to symptom onset‡ 24.6 (7.9) 8.6 (2.5) NA UHDRS motor score 0.7 (1.0) 1.4 (0.9) NA UHDRS verbal fluency 39.9 (11.7) 32.9 (8.7) 39.4 (6.4) UHDRS symbol-digit 57.3 (10.0) 44.9 (8.8) 52.4 (10.9) UHDRS stroop interference 50.9 (13.1) 37.1 (12.2) 44.0 (7.5) Note.—NA indicates not applicable; UHDRS, Unified HD Rating Scale. Data are the mean (standard deviation).
* Close participants were significantly older than far participants (P < .05).
† Close participants had a significantly longer CAG repeat size than that of far participants (P < .05).
‡ In the close group, onset was predicted significantly earlier than in the far group (P < .001).
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