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Research ArticleBrain

fMRI Biomarker of Early Neuronal Dysfunction in Presymptomatic Huntington’s Disease

Jane S. Paulsen, Janice L. Zimbelman, Sean C. Hinton, Douglas R. Langbehn, Catherine L. Leveroni, Michelle L. Benjamin, Norman C. Reynolds and Stephen M. Rao
American Journal of Neuroradiology November 2004, 25 (10) 1715-1721;
Jane S. Paulsen
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Janice L. Zimbelman
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Sean C. Hinton
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Douglas R. Langbehn
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Catherine L. Leveroni
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Michelle L. Benjamin
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Norman C. Reynolds
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Stephen M. Rao
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    Fig 1.

    Mean percentage of correct responses and reaction times for T and P tasks for the control, far, and close groups. Asterisk indicates close < control participants (P < .05).

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    Fig 2.

    Mean volumes of the left and right heads of the caudate for the control, far, and close groups. Asterisk indicates close < control participants (P < .05).

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    Fig 3.

    Activation foci (P < .01) derived from the T-minus-C comparison for the control, far, and close groups. Top row, Axial sections are 6 mm superior to the anterior commissure–posterior commissure line. Bottom row, Sections represent the midsagittal plane.

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    Fig 4.

    Volume of activation in the thalamus, caudate/putamen, and pre-SMA/cingulate derived from the time-minus-control subtraction for the control, far, and close groups.

Tables

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  • Subject demographics, CAG repeat size, and test scores

    MeasureParticipants
    FarCloseControl
    Age (years)*33.0 (5.0)41.1 (5.9)38.0 (6.1)
    Education (years)14.6 (2.4)14.1 (1.7)14.9 (1.9)
    Sex (M/F)(2/5)(4/3)(2/5)
    CAG repeat size†41.3 (2.1)44.2 (2.5)NA
    Estimated years to symptom onset‡24.6 (7.9)8.6 (2.5)NA
    UHDRS motor score0.7 (1.0)1.4 (0.9)NA
    UHDRS verbal fluency39.9 (11.7)32.9 (8.7)39.4 (6.4)
    UHDRS symbol-digit57.3 (10.0)44.9 (8.8)52.4 (10.9)
    UHDRS stroop interference50.9 (13.1)37.1 (12.2)44.0 (7.5)
    • Note.—NA indicates not applicable; UHDRS, Unified HD Rating Scale. Data are the mean (standard deviation).

    • * Close participants were significantly older than far participants (P < .05).

    • † Close participants had a significantly longer CAG repeat size than that of far participants (P < .05).

    • ‡ In the close group, onset was predicted significantly earlier than in the far group (P < .001).

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American Journal of Neuroradiology: 25 (10)
American Journal of Neuroradiology
Vol. 25, Issue 10
1 Nov 2004
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Cite this article
Jane S. Paulsen, Janice L. Zimbelman, Sean C. Hinton, Douglas R. Langbehn, Catherine L. Leveroni, Michelle L. Benjamin, Norman C. Reynolds, Stephen M. Rao
fMRI Biomarker of Early Neuronal Dysfunction in Presymptomatic Huntington’s Disease
American Journal of Neuroradiology Nov 2004, 25 (10) 1715-1721;

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fMRI Biomarker of Early Neuronal Dysfunction in Presymptomatic Huntington’s Disease
Jane S. Paulsen, Janice L. Zimbelman, Sean C. Hinton, Douglas R. Langbehn, Catherine L. Leveroni, Michelle L. Benjamin, Norman C. Reynolds, Stephen M. Rao
American Journal of Neuroradiology Nov 2004, 25 (10) 1715-1721;
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