Article Figures & Data
Figures
- Fig 1.
Setting of regions of interest and representative images of CBF, CBV, and MTT. On the CBF map on perfusion CT scans, a round small region of interest was set at the region with decreased CBF in the territory of the lenticulostriate artery (region of interest 1 [ROI-1]). Another region of interest was set in the mirror position to region of interest 1 in the contralateral hemisphere (region of interest 2 [ROI-2]). Using these two regions of interest, CBF, CBV, and MTT were measured. MRI, MR image.
- Fig 2.
Changes of infarction size on MR images (MRI). Infarction sizes were measured on initial FLAIR images and follow-up T2-weighted MR images. Significant difference was shown between the two groups in infarction size on follow-up MR images (P = .037) but not on initial MR images (P = .814). n.s., not significant.
- Fig 3.
Comparison of CBF, CBV, and MTT in control and progress groups. Significant difference was shown in MTT value between the two groups (P < .001) but not in CBF value (P = .052) or CBV value (P = .349) in region of interest 1. Significant differences were shown between the two groups in CBF ratio (P = .016) and MTT ratio (P < .001) but not in CBV ratio (P = .695). n.s., not significant.
- Fig 4.
Relationships between CBF and MTT ratio. With cutoff lines at <0.76 in the CBF ratio and at >1.26 in the MTT ratio, sensitivity was 76.3%, specificity was 92.3%, positive predictive value was 90.9%, and negative predictive value was 80.8%.
Tables
Control (n = 13) Progress (n = 13) P value* Age (yr) 69.5 ± 7.8 70.1 ± 7.4 0.830 Sex n (%) M, 9 (69.2); F, 4 (30.8) M, 7 (53.8); F, 6 (46.2) 0.419 Cardiac disease n (%) 1 (7.7) 2 (15.4) 0.538 Diabetes n (%) 3 (23.1) 2 (15.4) 0.618 Hypertension n (%) 8 (61.5) 9 (69.2) 0.680 Hypercholesterolemia n (%) 5 (38.5) 2 (15.4) 0.179 Antiplatelet n (%) 3 (23.1) 4 (30.8) 0.658 Smoking n (%) 5 (38.5) 3 (23.1) 0.394 Previous cerebral disease n (%) 4 (30.8) 4 (30.8) Admission NIHSS (points) 2.2 ± 0.8 2.0 ± 0.8 0.615 Time to perfusion CT (hr) 9.8 ± 8.4 10.2 ± 6.9 0.837 Note.—M indicates male; F, female; NIHSS, National Institute of Health Stroke Scale. All values are expressed as number of patients (percentage) or average ± SD.
* Logistic analysis was conducted for the control and progress groups.
- TABLE 2:
Summary of infarction size, values, and ratios of cerebral blood flow, cerebral blood volume, and mean transit time
Control (n = 13) Progress (n = 13) P value* Infarction size on MR image Initial FLAIR image (mm2) 50.8 ± 21.7 48.7 ± 21.0 0.814 Follow-up T2WI (mm2) 53.5 ± 21.4 78.3 ± 34.3 0.037 Value and ratio on perfusion CT scan CBF value (ml/100 g/min) 26.1 ± 7.0 19.6 ± 9.0 0.052 CBV value (ml/100 g) 4.3 ± 0.9 4.8 ± 1.9 0.349 MTT value (second) 10.0 ± 1.3 14.5 ± 3.5 <0.001 CBF ratio 0.9 ± 0.1 0.6 ± 0.2 0.016 CBV ratio 1.0 ± 0.2 1.0 ± 0.3 0.695 MTT ratio 1.1 ± 0.1 1.5 ± 0.4 <0.001 Note.—FLAIR indicates fluid-attenuated inversion recovery; T2WI, T2-weighted image; CBF, cerebral blood flow; CBV, cerebral blood volume; MTT, mean transit time. All values are expressed as average ± SD.
* The differences in value and ratio of cerebral blood flow, cerebral blood volume, and mean transit time were analyzed statistically between the two groups by using the unpaired Student’s t test.
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